Results 261 to 270 of about 1,051,691 (340)

Beyond amyloid: nanobody-mediated neuroinflammatory therapy for Alzheimer's disease. [PDF]

Transl Neurodegener
Amniouel S, Suh J, Zheng W, Zhang Q.
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

A cytotoxic peptide-drug conjugate for tumor-specific delivery of co-injected molecules. [PDF]

PLoS One
Miyamura N, Yamazaki CM, Anami Y, Tsuchikama K, Sugahara KN.   +4 more
europepmc   +1 more source

Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota

Advanced Chinese Medicine, EarlyView.
Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time‐honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders.
Jinlan Di, Xiaochun Zhang
wiley   +1 more source

A Novel Hybrid LC-MS/MS Methodology for the Quantitative Bioanalysis of Antibody-siRNA Conjugates. [PDF]

Anal Chem
Song Z, Yuan L.
europepmc   +1 more source

Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Ocrelizumab (OCR), a humanized anti‐CD20 monoclonal antibody, is highly efficient in relapsing–remitting multiple sclerosis (RR‐MS). We assessed early cellular B‐cell profiles in patients prior to OCR treatment, on OCR treatment, and after 15 months of therapy discontinuation.
Alexandra Garcia, Stephane Rodriguez, Emilie Dugast, Christine Lebrun‐Frenay, Eric Thouvenot, Jérôme de Sèze, Emmanuelle Le Page, Sandra Vukusic, Inès Doghri, Eric Berger, Olivier Casez, Pierre Labauge, Aurélie Ruet, Catarina Raposo, Fabienne Le Frère, Arnaud B. Nicot, Sandrine Wiertlewski, Pierre‐Antoine Gourraud, Laure Michel, Laureline Berthelot, David‐Axel Laplaud   +20 more
wiley   +1 more source

Comprehensive Characterization and Biological and Safety Evaluation of Zinc Oxide-Curcumin Nanoconjugates: Unraveling Synergistic Effects for Enhanced Therapeutic Applications. [PDF]

ACS Omega
Rajendran D, Shobha M, Mohana S, Gopi M, Ramachandran N, Franklin MEE, Manimaran A, Huliyurdurga Shameeulla H, Selvaraju S, Sahoo A.   +9 more
europepmc   +1 more source

Bilateral versus Unilateral Training With Rhythmic Auditory Cueing in Stroke Rehabilitation: Effects on Upper Limb Function and Interhemispheric Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stroke is a leading cause of long‐term disability in adults, with upper limb hemiparesis being a common impairment. Traditional training is mostly aimed at paralyzed limbs, but the effect of bilateral training is still unclear.
Fangfang Qian, Yanhong Dai, Guoqiang Zheng, Qi Zhong, Jianliang Lu, Luying Hu, Youhua He, Zhuoming Chen   +7 more
wiley   +1 more source

⁶⁸Ga-radiolabeled fluorescent dye for potential non-invasive multimodal imaging of subarachnoid hemorrhage. [PDF]

EJNMMI Radiopharm Chem
Gerhards JW, Schäfer L, Kang D, Lindauer U, Lütje S, Mottaghy FM, Schmidt T, Vogg ATJ.   +7 more
europepmc   +1 more source