Results 41 to 50 of about 1,526,980 (375)

Conjugate vaccines

Expert Review of Vaccines, 2003
Conjugate vaccines in which the capsular polysaccharide of Haemophilus influenzae type b, common serotypes of Streptococcus pneumoniae and group C Neisseria meningitidis are covalently bound to a protein antigen to convert a T-cell-independent immune response into a T-cell-dependent response have proved highly effective in the prevention of invasive ...
openaire   +2 more sources

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate

Molecules, 2006
Direct, solid phase synthesis of an oligonucleotide conjugate of the antibioticdrug metronidazole was accomplished by the phosphoramidite method. Removal ofprotecting groups and cleavage from the controlled pore glass (CPG) solid support wassuccessful ...
William Fraser, Michael L. Davis, Andrew J. Walsh   +2 more
doaj   +1 more source

Conjugate Inequalities

Rocky Mountain Journal of Mathematics, 2003
The paper under review contains a large generalization of a result due to \textit{J. Brink} [see Pac. J. Math. 42, 289--312 (1972; Zbl 0218.26012)], concerning the problem of best constants in the inequalities \(\left\| f\right\| _{L^{p}}\leq M(n,p,q)\left\| f^{(n)}\right\| _{L^{q}}\) on the interval \([0,1],\) with the boundary conditions \[ f^{(k)}(0)
openaire   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Immunogenicity and protective efficacy against Salmonella C2-C3 infection in mice immunized with a glycoconjugate of S. Newport Core-O polysaccharide linked to the homologous serovar FliC protein

Human Vaccines & Immunotherapeutics, 2019
Nontyphoidal Salmonella (NTS) are important human enteric pathogens globally. Among the different serovars associated with human NTS disease, S. Newport (a serogroup C2-C3 Salmonella) accounts for a measurable proportion of cases.
Ofir Schuster, Khandra T. Sears, Girish Ramachandran, Fabien J. Fuche, Brittany Curtis, Sharon M. Tennant, Raphael Simon   +6 more
doaj   +1 more source

Poly (l-γ-glutamylglutamine) Polymer Enhances Doxorubicin Accumulation in Multidrug Resistant Breast Cancer Cells

Molecules, 2016
Background: Drug resistance is one of the bottlenecks of cancer chemotherapy in the clinic. Polymeric nanomedicine is one of the most promising strategies for overcoming poor chemotherapy responses due to the multidrug resistance (MDR).
Ting Peng, Kai Liu, Liefang Gao, Lipeng Gao, Jing Chen, Jing Wang, Yu Liu, Yiting Wang, Zhiqiang Yan, Lei Yu   +9 more
doaj   +1 more source

On the mechanisms of conjugate vaccines

Proceedings of the National Academy of Sciences of the United States of America, 2018
During the last three decades, the development and commercialization of conjugate vaccines against Haemophilus influenzae type b (Hib), pneumococcus, and serogroups C, A, W, and Y of meningococcus contributed to the virtual elimination of bacterial ...
R. Rappuoli, E. De Gregorio, P. Costantino   +2 more
semanticscholar   +1 more source

Conjugation in semigroups

Journal of Algebra, 2014
The action of any group on itself by conjugation and the corresponding conjugacy relation play an important role in group theory. There have been several attempts to extend the notion of conjugacy to semigroups. In this paper, we present a new definition of conjugacy that can be applied to an arbitrary semigroup and it does not reduce to the universal ...
João Araújo, Janusz Konieczny, António Malheiro   +2 more
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source