Results 41 to 50 of about 1,051,691 (340)

Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate

open access: yesMolecules, 2006
Direct, solid phase synthesis of an oligonucleotide conjugate of the antibioticdrug metronidazole was accomplished by the phosphoramidite method. Removal ofprotecting groups and cleavage from the controlled pore glass (CPG) solid support wassuccessful ...
William Fraser   +2 more
doaj   +1 more source

How Computations Can Assist the Rational Design of Drugs for Photodynamic Therapy: Photosensitizing Activity Assessment of a Ru(II)-BODIPY Assembly

open access: yesMolecules, 2022
Ruthenium-based complexes represent a new frontier in light-mediated therapeutic strategies against cancer. Here, a density functional-theory-based computational investigation, of the photophysical properties of a conjugate BODIPY-Ru(II) complex, is ...
Fortuna Ponte   +4 more
doaj   +1 more source

State estimation from pair of conjugate qudits [PDF]

open access: yes, 2006
We show that, for $N$ parallel input states, an anti-linear map with respect to a specific basis is essentially a classical operator. We also consider the information contained in phase-conjugate pairs $|\phi > |\phi^*>$, and prove that there is more ...
D. J. Griffiths   +5 more
core   +1 more source

The unpredictably eruptive dynamics of spruce budworm populations in eastern Canada

open access: yesPopulation Ecology, EarlyView.
We examine historical population data for spruce budworm from several locations through the period 1930–1997, and use density‐dependent recruitment curves to test whether the pattern of population growth over time is more consistent with Royama's (1984; Ecological Monographs 54:429–462) linear R(t) model of harmonic oscillation at Green River New ...
Barry J. Cooke, Jacques Régnière
wiley   +1 more source

Immunogenicity and protective efficacy against Salmonella C2-C3 infection in mice immunized with a glycoconjugate of S. Newport Core-O polysaccharide linked to the homologous serovar FliC protein

open access: yesHuman Vaccines & Immunotherapeutics, 2019
Nontyphoidal Salmonella (NTS) are important human enteric pathogens globally. Among the different serovars associated with human NTS disease, S. Newport (a serogroup C2-C3 Salmonella) accounts for a measurable proportion of cases.
Ofir Schuster   +6 more
doaj   +1 more source

Poly (l-γ-glutamylglutamine) Polymer Enhances Doxorubicin Accumulation in Multidrug Resistant Breast Cancer Cells

open access: yesMolecules, 2016
Background: Drug resistance is one of the bottlenecks of cancer chemotherapy in the clinic. Polymeric nanomedicine is one of the most promising strategies for overcoming poor chemotherapy responses due to the multidrug resistance (MDR).
Ting Peng   +9 more
doaj   +1 more source

Conjugate Points in Length Spaces

open access: yes, 1994
In this paper we extend the concept of a conjugate point in a Riemannian manifold to complete length spaces (also known as geodesic spaces). In particular, we introduce symmetric conjugate points and ultimate conjugate points. We then generalize the long
Shankar, Krishnan, Sormani, Christina
core   +1 more source

4D Doubleton Conformal Theories, CPT and IIB String on AdS_5 X S^5 [PDF]

open access: yes, 1998
We study the unitary supermultiplets of the N=8, d=5 anti-de Sitter (AdS) superalgebra SU(2,2|4) which is the symmetry algebra of the IIB string theory on AdS_5 X S^5.
Angelopoulos   +42 more
core   +2 more sources

Speciation Through the Lens of Population Dynamics: A Theoretical Primer on How Small and Large Populations Diverge

open access: yesPopulation Ecology, EarlyView.
Population size and dynamics fundamentally shape speciation by influencing genetic drift, founder events, and adaptive potential. Small populations may speciate rapidly due to stronger drift, whereas large populations harbor more genetic diversity, which can alter divergence trajectories. We highlight theoretical models that incorporate population size
Ryo Yamaguchi   +3 more
wiley   +1 more source

Synthesis of Novel Artemisinin, Ciprofloxacin, and Norfloxacin Hybrids with Potent Antiplasmodial Activity

open access: yesAntibiotics
The synthesis and antiplasmodial evaluation of new hybrids combining the pharmacophore structures of artemisinin, ciprofloxacin or norfloxacin, and 7-chloroquinoline are reported in this study. The first step for all of the syntheses is the obtainment of
Georgia Vamvoukaki   +6 more
doaj   +1 more source

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