Results 181 to 190 of about 100,362 (316)

Provincial Trends in Childhood Vaccine Coverage in Afghanistan From 2000 to 2024: An Ecological Study of Findings From the Institute for Health Metrics and Evaluation. [PDF]

Cureus
Khan A, Tidman M.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

CDCA-Derived NE3TA Conjugate for Liver-Selective ⁶⁴Cu PET Imaging. [PDF]

ACS Omega
Wang H, Ren S, Bandara N, Zhang S, Fujimori R, Nguyen HH, Minh DDL, Rogers BE, Chong HS.   +8 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Evaluating neoantigen-vaccine responses through mechanistic and model-based frameworks. [PDF]

NPJ Precis Oncol
Ibrahim EIK, Laurén I, Veerman RE, Jönsson S, Ytterberg AJ, Lindqvist A, Mangsbo SM, Friberg LE.   +7 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preclinical evaluation of a bivalent conjugate vaccine against <i>Salmonella</i> Typhi and Paratyphi A. [PDF]

Front Immunol
Alfini R, Di Benedetto R, Carducci M, Paradkar V, Mallubhotla H, Renukuntla S, Patel D, Manoharan S, Panchakshari M, Kyasani M, Sengupta N, Martin LB, Rossi O, Rondini S, Giannelli C, Micoli F.   +15 more
europepmc   +1 more source

Implementation of Modified Conjugate Gradient Algorithm and Analysis of Convergence in Electromagnetic Tomography Lab System

, 2013
: Electromagnetic tomography technology is a new process tomography technology. The aim of this study is to develop a new image reconstruction algorithm suitable to electromagnetic tomography and verify its convergence.
Li Liu, Wang Zhan-Jun
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Bimodal Fluorescent Conjugate Based on Prostate-Specific Membrane Antigen Ligands with the Chelating Agent DOTA and SulfoCy5 Dye: Synthesis, Radiolabeling, and Biological Activity. [PDF]

Int J Mol Sci
Machulkin AE, Petrov SA, Butakova NS, Lunev AS, Petrosova KA, Shafikov RR, Skvortsov DA, Mitrofanov IA, Ivashkovaskaia MN, Beloglazkina EK, Larenkov AA.   +10 more
europepmc   +1 more source