Results 41 to 50 of about 73,090 (262)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
An Accelerated Riemannian Conjugate Gradient Method Based on the Barzilai–Borwein Technique
MathematicsThis paper proposes an accelerated Riemannian conjugate gradient method based on the Barzilai-Borwein (BB) technique, termed ABBSRCG, for unconstrained optimization on Riemannian manifolds. Building upon classical Riemannian conjugate gradient frameworks,
Ziyin Ma, Tao Yan, Shimin Zhao
doaj +1 more source
Differentiating through conjugate gradient [PDF]
Optimization Methods and Software, 2018 We show that, although the conjugate gradient (CG) algorithm has a singularity at the solution, it is possible to differentiate forward through the algorithm automatically by re-declaring all the v...
openaire +1 more source
A Deflated Version of the Conjugate Gradient Algorithm [PDF]
SIAM Journal on Scientific Computing, 2000 A deflated version of the conjugate gradient algorithm is presented for solving linear systems. The algorithm is useful when a small number of eigenvalues of the iteration matrix are very close to the origin and in cases when multiple right-hand sides are present.
Saad, Y. +3 more
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Two Versions of the Spectral Nonlinear Conjugate Gradient Method
Al-Mustansiriyah Journal of Science, 2018 The nonlinear conjugate gradient method is widely used to solve unconstrained optimization problems. In this paper the development of different versions of nonlinear conjugate gradient methods with global convergence properties proved.
Basim A. Hassan, Haneen A. Alashoor
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A Modified Bat Algorithm with Conjugate Gradient Method for Global Optimization
International Journal of Mathematics and Mathematical Sciences, 2020 Metaheuristic algorithms are used to solve many optimization problems. Firefly algorithm, particle swarm improvement, harmonic search, and bat algorithm are used as search algorithms to find the optimal solution to the problem field.
Huda I. Ahmed +2 more
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