Results 61 to 70 of about 265,361 (282)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A Modified Bat Algorithm with Conjugate Gradient Method for Global Optimization

International Journal of Mathematics and Mathematical Sciences, 2020
Metaheuristic algorithms are used to solve many optimization problems. Firefly algorithm, particle swarm improvement, harmonic search, and bat algorithm are used as search algorithms to find the optimal solution to the problem field.
Huda I. Ahmed, Eman T. Hamed, Hamsa Th. Saeed Chilmeran   +2 more
doaj   +1 more source

Stability Analysis Of Continuous Conjugate Gradient Method [PDF]

, 2008
Kaedah Conjugate Gradient adalah sangat berguna untuk: menyelesaikan masalah tiada kekangan paling optimum yang berskala besar. Walaubagaimanapun, carlan garis (line search) dalam Kaedah Conjugate Gradient kadang-kadang sukar didapati dan pengiraannya
Harun, Nurzalina
core  

Chronological Inversion Method for the Dirac Matrix in Hybrid Monte Carlo

, 1996
In Hybrid Monte Carlo simulations for full QCD, the gauge fields evolve smoothly as a function of Molecular Dynamics time. Here we investigate improved methods of estimating the trial or starting solutions for the Dirac matrix inversion as superpositions
A.R. Levi, Batroumi, Brower, Callaway, DeGrand, Duane, Duane, Duane, Duane, Golub, Gottlieb, Gottlieb, Gupta, Gupta, Gupta, Gupta, Gupta, Gupta, Hill, Jazwinski, K.N. Orginos, Lüscher, Mawhinney, Parisi, Polonyi, R.C. Brower, Santayana, T. Ivanenko   +27 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Enhancing Conjugate Gradient Method Through a Novel Investigation Parameter For Unconstrained Minimization [PDF]

مجلة التربية والعلم
Conjugate gradient algorithms come in a wide range of flavors. The conjugate gradient technique primarily concentrates on the spectral parameter. It follows the standard method proposed by Hastens and Stiefel, In this study, we have devised an innovative
Abd Hassan, Hamsa Saeed
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Three Proposed Hybrid Genetic Algorithms [PDF]

Al-Rafidain Journal of Computer Sciences and Mathematics, 2013
Genetic Algorithm has been hybridized with classical optimization methods. Hybridization has been done in three approaches, by using conjugate gradient algorithm for Fletcher and Reeves, second by using steepest descent method and lastly by creation of ...
Ban Mitras, Nada Hassan
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source