Results 61 to 70 of about 888,833 (294)
A Deflated Version of the Conjugate Gradient Algorithm [PDF]
SIAM Journal on Scientific Computing, 2000 A deflated version of the conjugate gradient algorithm is presented for solving linear systems. The algorithm is useful when a small number of eigenvalues of the iteration matrix are very close to the origin and in cases when multiple right-hand sides are present.
Saad, Y. +3 more
openaire +3 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Journal of Applied Mathematics, 2013 The conjugate gradient (CG) method has played a special role in solving large-scale nonlinear optimization problems due to the simplicity of their very low memory requirements.
Shengwei Yao, Xiwen Lu, Zengxin Wei
doaj +1 more source
Two Versions of the Spectral Nonlinear Conjugate Gradient Method
Al-Mustansiriyah Journal of Science, 2018 The nonlinear conjugate gradient method is widely used to solve unconstrained optimization problems. In this paper the development of different versions of nonlinear conjugate gradient methods with global convergence properties proved.
Basim A. Hassan, Haneen A. Alashoor
doaj +1 more source
Least-squares-based three-term conjugate gradient methods
Journal of Inequalities and Applications, 2020 In this paper, we first propose a new three-term conjugate gradient (CG) method, which is based on the least-squares technique, to determine the CG parameter, named LSTT.
Chunming Tang, Shuangyu Li, Zengru Cui
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Enhancing Conjugate Gradient Method Through a Novel Investigation Parameter For Unconstrained Minimization [PDF]
مجلة التربية والعلمConjugate gradient algorithms come in a wide range of flavors. The conjugate gradient technique primarily concentrates on the spectral parameter. It follows the standard method proposed by Hastens and Stiefel, In this study, we have devised an innovative
Abd Hassan, Hamsa Saeed
doaj +1 more source