Results 71 to 80 of about 73,090 (262)

An Adaptive MultiPreconditioned Conjugate Gradient Algorithm [PDF]

SIAM Journal on Scientific Computing, 2016
Summary: This article introduces and analyzes a new adaptive algorithm for solving symmetric positive definite linear systems in cases where several preconditioners are available or the usual preconditioner is a sum of contributions. A new theoretical result allows us to select, at each iteration, whether a classical preconditioned conjugate gradient ...
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Nonlinear conjugate gradient methods in micromagnetics

AIP Advances, 2017
Conjugate gradient methods for energy minimization in micromagnetics are compared. The comparison of analytic results with numerical simulation shows that standard conjugate gradient method may fail to produce correct results. A method that restricts the
J. Fischbacher, Alexander Kovacs, Harald Oezelt, T. Schrefl, L. Exl, J. Fidler, D. Suess, N. Sakuma, M. Yano, A. Kato, T. Shoji, A. Manabe   +11 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Development of a Spectral Conjugate Gradient Method for Solving Optimization Problems

Al-Rafidain Journal of Computer Sciences and Mathematics
Conjugate gradient methods have been favored to use for their efficiency in solving large-scale unconstrained optimization problems, primarily because of their low memory requirements and exclusive to use the first-order derivative information.
Kamal Jameel Murad, Salah Gazi Shareef
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A Novel Conjugate Gradient Algorithm as a Convex Combination of Classical Conjugate Gradient Methods

Kurdistan Journal of Applied Research
Conjugate gradient (CG) algorithms are constructive for handling large-scale nonlinear optimization problems. One optimization technique intended to address unconstrained optimization issues effectively is the hybrid conjugate gradient (HCG) algorithm ...
Sara Sahib Mohammed Zaki, Hawraz Nadhim Jabbar , Sozan Saber Haider   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Image Noise Reduction and Solution of Unconstrained Minimization Problems via New Conjugate Gradient Methods

Mathematics
The conjugate gradient (CG) directions are among the important components of the CG algorithms. These directions have proven their effectiveness in many applications—more specifically, in image processing due to their low memory requirements.
Bassim A. Hassan, Issam A. R. Moghrabi, Thaair A. Ameen, Ranen M. Sulaiman, Ibrahim Mohammed Sulaiman   +4 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source