Results 91 to 100 of about 888,833 (294)

Conjugate gradient method for the linear complementarity problem with S-matrix

, 2008
In this paper, we present a conjugate gradient method for solving the linear complementarity problem that involves an S-matrix. At each step, we solve a lower-dimensional system of linear equations by conjugate gradient method.
Li DH(李董辉), Nie YY(聂义勇), Zeng JP(曾经平), Qing-Na Li   +3 more
core  

Development of a Spectral Conjugate Gradient Method for Solving Optimization Problems

Al-Rafidain Journal of Computer Sciences and Mathematics
Conjugate gradient methods have been favored to use for their efficiency in solving large-scale unconstrained optimization problems, primarily because of their low memory requirements and exclusive to use the first-order derivative information.
Kamal Jameel Murad, Salah Gazi Shareef
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Efficient non-linear 3D electrical tomography reconstruction

, 2001
Non-linear electrical tomography imaging can be performed efficiently if certain optimisations are applied to the computational reconstruction process. We present a 3D non-linear reconstruction algorithm based on a regularized conjugate gradient solver ...
Blott, B H, Daniell, G.J., Molinari, M, Daniell, G J, Cox, SJ J, Molinari, M., Cox, S.J., Blott, B.H.   +7 more
core   +1 more source

A Novel Conjugate Gradient Algorithm as a Convex Combination of Classical Conjugate Gradient Methods

Kurdistan Journal of Applied Research
Conjugate gradient (CG) algorithms are constructive for handling large-scale nonlinear optimization problems. One optimization technique intended to address unconstrained optimization issues effectively is the hybrid conjugate gradient (HCG) algorithm ...
Sara Sahib Mohammed Zaki, Hawraz Nadhim Jabbar , Sozan Saber Haider   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Nonlinear Conjugate Gradient Methods

, 2015
Modifications of nonlinear conjugate gradient method are described and ...
Lukšan, Ladislav
core  

Image Noise Reduction and Solution of Unconstrained Minimization Problems via New Conjugate Gradient Methods

Mathematics
The conjugate gradient (CG) directions are among the important components of the CG algorithms. These directions have proven their effectiveness in many applications—more specifically, in image processing due to their low memory requirements.
Bassim A. Hassan, Issam A. R. Moghrabi, Thaair A. Ameen, Ranen M. Sulaiman, Ibrahim Mohammed Sulaiman   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source