Results 91 to 100 of about 845,583 (297)
Stability Analysis Of Continuous Conjugate Gradient Method [PDF]
, 2008 Kaedah Conjugate Gradient adalah sangat berguna untuk: menyelesaikan masalah tiada kekangan paling optimum yang berskala besar. Walaubagaimanapun, carlan garis (line search) dalam Kaedah Conjugate Gradient kadang-kadang sukar didapati dan pengiraannya
Harun, Nurzalina
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MathematicsThe conjugate gradient (CG) directions are among the important components of the CG algorithms. These directions have proven their effectiveness in many applications—more specifically, in image processing due to their low memory requirements.
Bassim A. Hassan +4 more
doaj +1 more source
Conjugate gradient method for the linear complementarity problem with S-matrix
, 2008 In this paper, we present a conjugate gradient method for solving the linear complementarity problem that involves an S-matrix. At each step, we solve a lower-dimensional system of linear equations by conjugate gradient method.
Li DH(李董辉) +3 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
New hybrid conjugate gradient method for nonlinear optimization with application to image restoration problems [PDF]
summary:The conjugate gradient method is one of the most effective algorithm for unconstrained nonlinear optimization problems. This is due to the fact that it does not need a lot of storage memory and its simple structure properties, which motivate us ...
Benterki, Djamel +2 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Nonlinear conjugate gradient methods [PDF]
, 2014 summary:Modifications of nonlinear conjugate gradient method are described and ...
Lukšan, Ladislav, Vlček, Jan
core +1 more source