Results 111 to 120 of about 84,313 (308)
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
On Meinardus’ examples for the conjugate gradient method [PDF]
Mathematics of Computation, 2007 The conjugate gradient (CG) method is widely used to solve a positive definite linear system A x = b
openaire +1 more source
An Improved Mixed Conjugate Gradient Method [PDF]
, 2012 Conjugate gradient method is an important and efficient method to solve the unconstrained optimization problems, especially for large scale problems.
Zong, Jizhou, Wang, Xiaodong, Jia, Wen
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Modified Conjugate Quantum Natural Gradient [PDF]
The efficient optimization of variational quantum algorithms (VQAs) is critical for their successful application in quantum computing. The Quantum Natural Gradient (QNG) method, which leverages the geometry of quantum state space, has demonstrated ...
Halla, Mourad
core +3 more sources
Conjugate directions for stochastic gradient descent [PDF]
, 2002 . The method of conjugate gradients provides a very effective way to optimize large, deterministic systems by gradient descent. In its standard form, however, it is not amenable to stochastic approximation of the gradient.
Thore Graepel, Nicol N. Schraudolph
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Programação paralela aplicada ao método N-Scheme para solução de problemas com o método de elementos finitos [PDF]
, 2012 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Elétrica, Florianópolis, 2012.Nesta tese é proposta uma nova técnica para resolução de problemas estáticos com o método de elementos ...
Eyng, Juliana
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source