FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
A new hybrid conjugate gradient method of unconstrained optimization methods [PDF]
, 2022 In this paper, we present a new hybrid method to solve a nonlinear unconstrained optimization problem by using conjugate gradient, which is a convex combination of Liu–Storey (LS) conjugate gradient method and Hager–Zhang (HZ) conjugate gradient method ...
Chenna Nasreddine +2 more
core
The global convergence of spectral RMIL conjugate gradient method for unconstrained optimization with applications to robotic model and image recovery. [PDF]
PLoS One, 2023 Salihu N +4 more
europepmc +1 more source
Learning Complexity of Gradient Descent and Conjugate Gradient Algorithms
Proceedings of the AAAI Conference on Artificial IntelligenceGradient Descent (GD) and Conjugate Gradient (CG) methods are among the most effective iterative algorithms for solving unconstrained optimization problems, particularly in machine learning and statistical modeling, where they are employed to minimize cost functions.
Xianqi Jiao, Jia Liu, Zhiping Chen
openaire +3 more sources
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
Estimation of undistorted images in brain echo-planar images with distortions using the conjugate gradient method with anatomical regularization. [PDF]
Med Phys, 2022 Kumazawa S, Yoshiura T.
europepmc +1 more source
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
, 2003 The paper introduces the main idea of the conjugate gradient method for solving large systems of linear algebraic ...
Křížek, Michal
core
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
A HS-PRP-Type Hybrid Conjugate Gradient Method with Sufficient Descent Property. [PDF]
Comput Intell Neurosci, 2021 Wu X, Zhu Y, Yin J.
europepmc +1 more source