Results 101 to 110 of about 845,583 (297)
A Modified Spectral Methods for Large-Scale UnconStrained
Al-Mustansiriyah Journal of Science, 2018 A modified spectral methods for solving unconstrained optimization problems based on the formulae are derived which are given in [4, 5]. The proposed methods satisfied the descent condition.
Basim A. Hassan, Haneen A. Alashoor
doaj +1 more source
A hardware acceleration technique for gradient descent and conjugate gradient [PDF]
, 2011 Gradient descent, conjugate gradient, and other iterative algorithms are a powerful class of algorithms; however, they can take a long time for conver- gence.
Kesler, David R.
core
Nonlinear conjugate gradient methods for unconstrained optimization
, 2020 Two approaches are known for solving large-scale unconstrained optimization problems—the limited-memory quasi-Newton method (truncated Newton method) and the conjugate gradient method.
Andrei, Neculai
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
On Meinardus’ examples for the conjugate gradient method [PDF]
Mathematics of Computation, 2007 The conjugate gradient (CG) method is widely used to solve a positive definite linear system A x = b
openaire +1 more source
Nonlinear conjugate gradient method [PDF]
, 2019 V této práci studujeme nelineární metody sdružených gradientů pro nepodmíněnou optimalizaci. Uvádíme možnosti a limity stávajících metod nepodmíněné optimalizace.
Aleksandr Efremov
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
The block conjugate gradient algorithm and related methods [PDF]
, 1980 The development of the Lanczos algorithm for finding eigenvalues of large sparse symmetric matrices was followed by that of block forms of the algorithm.
O'Leary, Dianne P., Zítko, Jan
core +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source