Results 121 to 130 of about 84,313 (308)

Towards Stochastic Conjugate Gradient Methods [PDF]

open access: yes, 2002
The method of conjugate gradients provides a very effective way to optimize large, deterministic systems by gradient descent. In its standard form, however, it is not amenable to stochastic approximation of the gradient.
Thore Graepel, Nicol N. Schraudolph
core  

Conjugate Gradient Method for Solving System of Nonlinear Equations [PDF]

open access: yes, 2005
In this thesis, the conjugate gradient method will be extended to solve symmetric and non-symmetric nonlinear equations. Several variations of the conjugate gradient method are introduced and investigated.
Honrao, Abhijit Prakash
core   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

A Modified Spectral Methods for Large-Scale UnconStrained

open access: yesAl-Mustansiriyah Journal of Science, 2018
A modified spectral methods for solving unconstrained optimization problems based on the formulae are derived which are given in [4, 5]. The proposed methods satisfied the descent condition.
Basim A. Hassan, Haneen A. Alashoor
doaj   +1 more source

A modified Fletcher-Reeves conjugate gradient method for unconstrained optimization with applications in image restoration [PDF]

open access: yes
summary:The Fletcher-Reeves (FR) method is widely recognized for its drawbacks, such as generating unfavorable directions and taking small steps, which can lead to subsequent poor directions and steps.
Hbaib, Mohamed   +2 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

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