FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Restarted primal-dual Newton conjugate gradient method for enhanced spatial resolution of reconstructed cone-beam x-ray luminescence computed tomography images. [PDF]
Phys Med Biol, 2020 Gao P +5 more
europepmc +1 more source
حول طریقة التدرج المزدوجة الجدیدة
Al-Rafidain Journal of Computer Sciences and Mathematics, 2009 Abbas Y. Al-Bayati +2 more
doaj +1 more source
A Novel Conjugate Gradient Algorithm as a Convex Combination of Classical Conjugate Gradient Methods
Kurdistan Journal of Applied ResearchConjugate gradient (CG) algorithms are constructive for handling large-scale nonlinear optimization problems. One optimization technique intended to address unconstrained optimization issues effectively is the hybrid conjugate gradient (HCG) algorithm ...
Sara Sahib Mohammed Zaki +2 more
doaj +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
طریقة للتدرج المترافق الطیفی ذات التقارب الشامل لحل مسائل الأمثلیة غیر المقیدة
Al-Rafidain Journal of Computer Sciences and Mathematics, 2013 Basim A. Hassan
doaj +1 more source
CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao +7 more
wiley +1 more source
Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni +19 more
wiley +1 more source
A Modified Conjugate Gradient Method for Unconstrained Optimization
, 2013 Conjugate gradient methods are an important class of methods for solving unconstrained optimization problems, especially for large-scale problems. Recently, they have been much studied.
Li, Can
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