Results 111 to 120 of about 65,656 (305)
SUBGRADIENT MINIMIZATION METHOD WITH DESCENT VECTORS CORRECTION BY MEANS OF TRAINING RELATIONS PAIRS
Вестник Кемеровского государственного университета, 2014 The paper introduces a conjugate subgradient method whose descent is corrected by a pair of current training relations. The convergence of the method is proved on strictly convex functions.
V. N. Krutikov, Ya. N. Vershinin
doaj
A scaled three-term conjugate gradient method for unconstrained optimization
Journal of Inequalities and Applications, 2016 Conjugate gradient methods play an important role in many fields of application due to their simplicity, low memory requirements, and global convergence properties.
Ibrahim Arzuka +2 more
doaj +1 more source
On three-term conjugate gradient method for optimization problems with applications on COVID-19 model and robotic motion control. [PDF]
Adv Contin Discret Model, 2022 Sulaiman IM +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
A Modified Conjugate Gradient Method for Unconstrained Optimization [PDF]
, 2013 Conjugate gradient methods are an important class of methods for solving unconstrained optimization problems, especially for large-scale problems. Recently, they have been much studied.
Li, Can
core +1 more source
Abstract and Applied Analysis, 2014 Combining the Rosen gradient projection method with the two-term Polak-Ribière-Polyak (PRP) conjugate gradient method, we propose a two-term Polak-Ribière-Polyak (PRP) conjugate gradient projection method for solving linear equality constraints ...
Zhifeng Dai
doaj +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
ANALISIS GRADIENT CONJUGATE METHOD UNTUK MINIMISASI FUNGSI [PDF]
, 2012 Abstrak Fungsi persamaan linier panjang Ax = y dengan A dan y adalah matriks merupakan fungsi yang mudah untuk dipecahkan jika nilai dari variabel x nya diketahui.
Jalil, Abdul
core +1 more source