Results 91 to 100 of about 11,641,221 (293)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Estimation of undistorted images in brain echo-planar images with distortions using the conjugate gradient method with anatomical regularization. [PDF]
Med Phys, 2022 Kumazawa S, Yoshiura T.
europepmc +1 more source
, 2008 Sparse signal approximations have become a fundamental tool in signal processing with wide ranging applications from source separation to signal acquisition.
Blumensath, T. +2 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
SUBGRADIENT MINIMIZATION METHOD WITH DESCENT VECTORS CORRECTION BY MEANS OF TRAINING RELATIONS PAIRS
Вестник Кемеровского государственного университета, 2014 The paper introduces a conjugate subgradient method whose descent is corrected by a pair of current training relations. The convergence of the method is proved on strictly convex functions.
V. N. Krutikov, Ya. N. Vershinin
doaj
A New Conjugate Gradient Projection Method for Convex Constrained Nonlinear Equations
Complexity, 2020 The conjugate gradient projection method is one of the most effective methods for solving large-scale monotone nonlinear equations with convex constraints.
Pengjie Liu, Jinbao Jian, Xianzhen Jiang
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A HS-PRP-Type Hybrid Conjugate Gradient Method with Sufficient Descent Property. [PDF]
Comput Intell Neurosci, 2021 Wu X, Zhu Y, Yin J.
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
A scaled three-term conjugate gradient method for unconstrained optimization
Journal of Inequalities and Applications, 2016 Conjugate gradient methods play an important role in many fields of application due to their simplicity, low memory requirements, and global convergence properties.
Ibrahim Arzuka +2 more
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Prior-Preconditioned Conjugate Gradient Method for Accelerated Gibbs Sampling in "Large n, Large p" Bayesian Sparse Regression. [PDF]
J Am Stat Assoc, 2023 Nishimura A, Suchard MA.
europepmc +1 more source