Results 81 to 90 of about 819,121 (316)

Nonlinear conjugate gradient methods in micromagnetics

AIP Advances, 2017
Conjugate gradient methods for energy minimization in micromagnetics are compared. The comparison of analytic results with numerical simulation shows that standard conjugate gradient method may fail to produce correct results. A method that restricts the
J. Fischbacher, Alexander Kovacs, Harald Oezelt, T. Schrefl, L. Exl, J. Fidler, D. Suess, N. Sakuma, M. Yano, A. Kato, T. Shoji, A. Manabe   +11 more
doaj   +1 more source

Block Preconditioning for the Conjugate Gradient Method [PDF]

SIAM Journal on Scientific and Statistical Computing, 1985
Different block preconditionings for the conjugate gradient methods are investigated for solving positive definite block tridiagonal systems. These preconditionings are based on different sparse approximate matrix inverses. The proposed methods are compared with other well-known preconditionings as for example the point incomplete Cholesky ...
Concus, P., Golub, G.H., Meurant, G.
openaire   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

An Accelerated Riemannian Conjugate Gradient Method Based on the Barzilai–Borwein Technique

Mathematics
This paper proposes an accelerated Riemannian conjugate gradient method based on the Barzilai-Borwein (BB) technique, termed ABBSRCG, for unconstrained optimization on Riemannian manifolds. Building upon classical Riemannian conjugate gradient frameworks,
Ziyin Ma, Tao Yan, Shimin Zhao
doaj   +1 more source

Chronological Inversion Method for the Dirac Matrix in Hybrid Monte Carlo

, 1996
In Hybrid Monte Carlo simulations for full QCD, the gauge fields evolve smoothly as a function of Molecular Dynamics time. Here we investigate improved methods of estimating the trial or starting solutions for the Dirac matrix inversion as superpositions
A.R. Levi, Batroumi, Brower, Callaway, DeGrand, Duane, Duane, Duane, Duane, Golub, Gottlieb, Gottlieb, Gupta, Gupta, Gupta, Gupta, Gupta, Gupta, Hill, Jazwinski, K.N. Orginos, Lüscher, Mawhinney, Parisi, Polonyi, R.C. Brower, Santayana, T. Ivanenko   +27 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A Novel hybridization of CG-techniques for Solving Unconstrained Optimization Problems

Wasit Journal for Pure Sciences
Conjugate gradient methods are an extremely helpful way for handling large scale non-linear optimization issues. In this paper, based on the three famous Dai-yuan (DY), Liu–Storey (LS)and Conjugate-Descent (CD) conjugate gradient methods, a new hybrid ...
Hawraz Jabbar
doaj   +1 more source

A New Smoothing Conjugate Gradient Method for Solving Nonlinear Nonsmooth Complementarity Problems

Algorithms, 2015
In this paper, by using the smoothing Fischer-Burmeister function, we present a new smoothing conjugate gradient method for solving the nonlinear nonsmooth complementarity problems.
Ajie Chu, Shouqiang Du, Yixiao Su
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source