Results 81 to 90 of about 11,641,221 (293)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Conjugate gradient method for the linear complementarity problem with S-matrix
, 2008 In this paper, we present a conjugate gradient method for solving the linear complementarity problem that involves an S-matrix. At each step, we solve a lower-dimensional system of linear equations by conjugate gradient method.
Li DH(李董辉) +3 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2002 In a recent paper [4], Li et al. gave a generalized successive overrelaxation (GSOR) method for the least squares problems. In this paper, the connection between the GSOR method and the preconditioned conjugate gradient (PCG) method for the normal ...
Li ZJ(李长军), Evans, DJ
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Fast Methods for Solving High Accuracy Surface Modeling
Journal of Algorithms & Computational Technology, 2013 High accuracy surface modeling (HASM) is a novel surface modeling method. The well known preconditioned conjugate gradient (PCG) method is used to solve the equations produced by HASM.
Na Zhao, Tian Xiang Yue
doaj +1 more source
Geodesy and Geodynamics, 2012 On the basis of Space-Wise Least Square method, three numerical methods including Cholesky decomposition, pre-conditioned conjugate gradient and Open Multi-Processing parallel algorithm are applied into the determination of gravity field with satellite ...
Zhu Guangbin +4 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
The global convergence of spectral RMIL conjugate gradient method for unconstrained optimization with applications to robotic model and image recovery. [PDF]
PLoS One, 2023 Salihu N +4 more
europepmc +1 more source