An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
An Accelerated Riemannian Conjugate Gradient Method Based on the Barzilai–Borwein Technique
MathematicsThis paper proposes an accelerated Riemannian conjugate gradient method based on the Barzilai-Borwein (BB) technique, termed ABBSRCG, for unconstrained optimization on Riemannian manifolds. Building upon classical Riemannian conjugate gradient frameworks,
Ziyin Ma, Tao Yan, Shimin Zhao
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A New Smoothing Conjugate Gradient Method for Solving Nonlinear Nonsmooth Complementarity Problems
Algorithms, 2015 In this paper, by using the smoothing Fischer-Burmeister function, we present a new smoothing conjugate gradient method for solving the nonlinear nonsmooth complementarity problems.
Ajie Chu, Shouqiang Du, Yixiao Su
doaj +1 more source
A New sufficient descent Conjugate Gradient Method for Nonlinear Optimization [PDF]
المجلة العراقية للعلوم الاحصائية, 2014 In this paper, a new conjugate gradient method based on exact step size which produces sufficient descent search direction at every iteration is introduced. We prove its global convergence, and give some results to illustrate its efficiency by comparing
Dr. Basim A. Hassan, Omer M. Esmaeel
doaj +1 more source
New hybrid conjugate gradient method for nonlinear optimization with application to image restoration problems [PDF]
summary:The conjugate gradient method is one of the most effective algorithm for unconstrained nonlinear optimization problems. This is due to the fact that it does not need a lot of storage memory and its simple structure properties, which motivate us ...
Benterki, Djamel +2 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A Novel hybridization of CG-techniques for Solving Unconstrained Optimization Problems
Wasit Journal for Pure SciencesConjugate gradient methods are an extremely helpful way for handling large scale non-linear optimization issues. In this paper, based on the three famous Dai-yuan (DY), Liu–Storey (LS)and Conjugate-Descent (CD) conjugate gradient methods, a new hybrid ...
Hawraz Jabbar
doaj +1 more source
Dai-Kou type conjugate gradient methods with a line search only using gradient
Journal of Inequalities and Applications, 2017 In this paper, the Dai-Kou type conjugate gradient methods are developed to solve the optimality condition of an unconstrained optimization, they only utilize gradient information and have broader application scope.
Yuanyuan Huang, Changhe Liu
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source