Results 51 to 60 of about 12,511,953 (289)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
A Mixed Spectral CD-DY Conjugate Gradient Method
Journal of Applied Mathematics, 2012 A mixed spectral CD-DY conjugate descent method for solving unconstrained optimization problems is proposed, which combines the advantages of the spectral conjugate gradient method, the CD method, and the DY method.
Liu Jinkui, Du Xianglin, Wang Kairong
doaj +1 more source
Algorithms, 2021 The conjugate gradient method is one of the most popular methods to solve large-scale unconstrained optimization problems since it does not require the second derivative, such as Newton’s method or approximations.
Zabidin Salleh +3 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Nonlinear conjugate gradient methods [PDF]
, 2014 summary:Modifications of nonlinear conjugate gradient method are described and ...
Lukšan, Ladislav, Vlček, Jan
core +1 more source
Symmetric Perry conjugate gradient method [PDF]
Computational Optimization and Applications, 2013 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Dongyi Liu, Genqi Xu
openaire +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Nonlinear Conjugate Gradient Methods with Wolfe Type Line Search
Abstract and Applied Analysis, 2013 Nonlinear conjugate gradient method is one of the useful methods for unconstrained optimization problems. In this paper, we consider three kinds of nonlinear conjugate gradient methods with Wolfe type line search for unstrained optimization problems ...
Yuan-Yuan Chen, Shou-Qiang Du
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Nonlinear conjugate gradient methods in micromagnetics
AIP Advances, 2017 Conjugate gradient methods for energy minimization in micromagnetics are compared. The comparison of analytic results with numerical simulation shows that standard conjugate gradient method may fail to produce correct results. A method that restricts the
J. Fischbacher +11 more
doaj +1 more source