Results 31 to 40 of about 24,071 (227)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Joint Detection, Tracking, and Classification of Multiple Extended Objects Based on the JDTC-PMBM-GGIW Filter

Remote Sensing, 2023
This paper focuses on the problem of joint detection, tracking, and classification (JDTC) for multiple extended objects (EOs) within a Poisson multi-Bernoulli (MB) mixture (PMBM) filter, where an EO is described as an ellipse, and the ellipse is modeled ...
Yuansheng Li, Ping Wei, Mingyi You, Yifan Wei, Huaguo Zhang   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Research on the Parameters Reconstruction Method of Pipe Structures Based on Intelligent Optimization Algorithms

Aerospace
Two reconstruction methods for constraint and load parameters of aero-engine pipelines based on intelligent optimization algorithms are proposed in this paper.
Shuxia Tian, Shunqiang Wang, Zhenmao Chen, Peng Zhang, Hong-En Chen, Xuan Gao, Shuai Liu   +6 more
doaj   +1 more source

Integrated assessment of the spring waters of the Bryansk region in the system of state monitoring

RUDN Journal of Ecology and Life Safety, 2022
The results of ecological-chemical and toxicological analysis of 20 model springs on the territory of urban and rural settlements of the Bryansk region within the framework of water monitoring are presented. Indicators of hydrochemistry and phytotoxicity
Olga A. Soboleva, Lidiya N. Anishchenko
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Optimal Design of Tooth Profile Parameter of Straight-conjugate Internal Gear Pair

Jixie chuandong, 2015
The optimal design of the straight-conjugate internal gear pair tooth profile parameter is carried out,the performance parameter functional equation of the straight-conjugate internal gear pair is analyzed.The optimization design mathematical model is ...
Hu Hanlin, Cui Jiankun, Xu Jinbo
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source