Results 61 to 70 of about 23,966 (226)

Model Characterization of High-Voltage Layer Heater for Electric Vehicles through Electro–Thermo–Fluidic Simulations

Energies
This paper focuses on the modeling and analysis of a high-voltage layer heater (HVLH) designed for environmentally friendly vehicles, including electric vehicles (EVs) and plug-in hybrid electric vehicles (PHEVs), through multiphysics simulations that ...
Kwon Joong Son
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

CALCULATION OF CONTACT TENSIONS IN CONJUGATE SURFACES IN SPHERE GLOBOIDAL RUSK SYNCHRONOUS CARDAN HINGE

Наука и техника, 2015
The paper presents  a calculation of contact tensions between conjugate surfaces in sphere globoidal rusk synchronous cardan hinge on the condition that there is power balance at the constant torque on the output shaft.
A. M. Saniotsky
doaj  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Buoyancy-Induced Heat Transfer inside Compressor Rotors: Overview of Theoretical Models

Aerospace, 2018
Increasing pressures in gas-turbine compressors, particularly in aeroengines where the pressure ratios can be above 50:1, require smaller compressor blades and an increasing focus on blade-clearance control.
J. Michael Owen, Hui Tang, Gary D. Lock   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

基于Pro/E的平面共轭凸轮机构设计及运动分析

Jixie chuandong, 2014
According to the characteristics and requirements of achieving mechanical movement,a plate conjugate discal cam mechanism is designed.The simple harmonic motion is selected as the movement patterns of follower parts.Based on analytical method,the work ...
曾鹏飞, 张星
doaj  

Construction of Combined Variable-Section Scroll Tooth Profiles Using Algebraic-Archimedes Double Spiral

Shanghai Jiaotong Daxue xuebao
The mathematical model of the profile is complicated and the connection conditions are not easily obtained by explicit calculation because different model parameters are used for different types of curves.
YAN Min, LIU Tao, MA Dequan, DANG Xu
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source