Results 51 to 60 of about 2,663,278 (338)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An improved Bayes empirical Bayes estimator

International Journal of Mathematics and Mathematical Sciences, 2003
Consider an experiment yielding an observable random quantity X whose distribution Fθ depends on a parameter θ with θ being distributed according to some distribution G0.
R. J. Karunamuni, N. G. N. Prasad
doaj   +1 more source

Bayesian estimation of Lorenz curve, Gini-index and variance of logarithms in a Pareto distribution

Statistica, 2007
In this article, we estimate Lorenz curve, Gini-index and variance of logarithms for Pareto distribution using Bayesian framework with a conjugate prior.
E. I. Abdul-Sathar, E. S. Jeevanand, K. R. Muraleedharan Nair   +2 more
doaj   +1 more source

X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates. [PDF]

PLoS ONE, 2007
The signal recognition particle (SRP) and its conjugate receptor (SR) mediate cotranslational targeting of a subclass of proteins destined for secretion to the endoplasmic reticulum membrane in eukaryotes or to the plasma membrane in prokaryotes ...
Christopher L Reyes, Earl Rutenber, Peter Walter, Robert M Stroud   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Variational Bayesian Quantile Regression with Non-Ignorable Missing Response Data

Axioms
For non-ignorable missing response variables, the mechanism of whether the response variable is missing can be modeled through logistic regression. In Bayesian computation, the lack of a conjugate prior for the logistic function poses a significant ...
Juanjuan Zhang, Weixian Wang, Maozai Tian   +2 more
doaj   +1 more source

Estimating correlations among demographic parameters in population models

Ecology and Evolution, 2019
Estimating correlations among demographic parameters is critical to understanding population dynamics and life‐history evolution, where correlations among parameters can inform our understanding of life‐history trade‐offs, result in effective applied ...
Thomas V. Riecke, Benjamin S. Sedinger, Perry J. Williams, Alan G. Leach, James S. Sedinger   +4 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Use of Wishart Prior and Simple Extensions for Sparse Precision Matrix Estimation. [PDF]

PLoS ONE, 2016
A conjugate Wishart prior is used to present a simple and rapid procedure for computing the analytic posterior (mode and uncertainty) of the precision matrix elements of a Gaussian distribution.
Markku Kuismin, Mikko J Sillanpää
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source