Results 91 to 100 of about 148,341 (304)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Ultra-Short Baseline Synthetic Aperture Passive Positioning Based on Interferometer Assistance

Remote Sensing
The synthetic aperture passive positioning (SAPP) method has attracted the attention of researchers due to its high positioning resolution. However, there are still key technical issues regarding SAPP methods, such as residual frequency offset (RFO ...
Gaogao Liu, Qidong Zhang, Jian Xu, Jiangbo Zhu, Ziyu Huang, Beibei Mu, Hongfu Guo   +6 more
doaj   +1 more source

Finite Element Analysis of Mixed Convection in a Rectangular Cavity with a Heat-Conducting Horizontal Circular Cylinder

Nonlinear Analysis, 2009
. Combined free and forced convection in a two dimensional rectangular cavity with a uniform heat source applied on the right vertical wall is studied numerically. A circular heat conducting horizontal cylinder is placed somewhere within the cavity.
Md. M. Rahman, M. A. Alim, M. A. H. Mamun   +2 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

FATIGUE LIFE ANALYSIS OF SHEARER PICKS BASED ON LOAD RECONSTRUCTION THEORY

Jixie qiangdu, 2018
In order to study the fatigue life of the shearer’pick in the actual working conditions,the load was reconstructed by using the analytical continuation principle.
MAO Jun, WANG Xin, CHEN HongYue, ZHANG Yu   +3 more
doaj  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

An Efficient and Regularized Modeling Method for Massive Scattered Data Combining Triangulated Irregular Network and Multiquadric Function

Mathematics
Spatial discrete data modeling plays a crucial role in geoscientific data analysis, with accuracy and efficiency being significant factors to consider in the modeling of massive discrete datasets.
Haifei Liu, Yuhao Zhang, Xin Liu, Ijaz Ahmed, Jianxin Liu   +4 more
doaj   +1 more source

Error Control of Iterative Linear Solvers for Integrated Groundwater Models

, 2010
An open problem that arises when using modern iterative linear solvers, such as the preconditioned conjugate gradient (PCG) method or Generalized Minimum RESidual method (GMRES) is how to choose the residual tolerance in the linear solver to be ...
Bai, Zhaojun, Brush, Charles, Chung, Francis, Dixon, Matthew, Dogrul, Emin, Kadir, Tariq   +5 more
core  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source