Results 171 to 180 of about 53,707 (310)

A Deep‐Red‐Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy Inducing Immunogenic Cell Death

Angewandte Chemie, EarlyView.
A deep‐red‐excited osmium(II) photosensitizer (Os2) induces immunogenic cell death (ICD) under 740 nm irradiation and triggers robust anti‐tumor immune responses both in vitro and in vivo. ABSTRACT Immunogenic cell death (ICD), which converts tumor cells into their own vaccine, plays a pivotal role in the development of novel anticancer therapies. Here,
Yiyi Zhang, Pierre Mesdom, Eduardo Izquierdo‐García, João P. M. António, Ruonan Gao, Bruno Saubaméa, Johanne Seguin, Morgane Moinard, Philippe Arnoux, Céline Frochot, Kevin Cariou, Bich‐Thuy Doan, Gilles Gasser   +12 more
wiley   +2 more sources

Preclinical evaluation of a bivalent conjugate vaccine against <i>Salmonella</i> Typhi and Paratyphi A. [PDF]

Front Immunol
Alfini R, Di Benedetto R, Carducci M, Paradkar V, Mallubhotla H, Renukuntla S, Patel D, Manoharan S, Panchakshari M, Kyasani M, Sengupta N, Martin LB, Rossi O, Rondini S, Giannelli C, Micoli F.   +15 more
europepmc   +1 more source

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

An overview of the clinical development of the 20-valent pneumococcal conjugate vaccine in adults. [PDF]

Hum Vaccin Immunother
McElwee K, Vojicic J, Sabharwal C, Ginis J, Peng Y, Mircus G, Watson W, Anderson A.   +7 more
europepmc   +1 more source

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

From Crisis to Control: A Study of Typhoid Conjugate Vaccine Efficacy in Harare, Zimbabwe (2017-2024). [PDF]

Open Forum Infect Dis
Bvochora T, Manyara J, Thilliez G, Vere M, Mukeredzi I, Nhamo D, Chitiyo F, Muzondo A, Juru A, Chonzi P, Phiri I, Smith AM, Chaibva BV, Mapingure M, Fuller W, Shrestha P, Nair P, Kingsley RA, Laxminarayan R, Musuka G, Mashe T.   +20 more
europepmc   +1 more source

Health Policy and Technological Change: Evidence from the Vaccine Industry [PDF]

Rapid technological progress has been a defining feature of the medical sector over the last century, yet we know little about the determinants of the development of these new technologies.
Amy Finkelstein
core  

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Examining epidemiological models and economic analyses of typhoid conjugate vaccine: A scoping review. [PDF]

PLOS Glob Public Health
Mandaliya P, Orangi S, Kazungu J, Waithaka D, Kairu A, Bationo A, Masiye F, Onwujekwe O, Barasa E.   +8 more
europepmc   +1 more source