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Impact of the conjugate vaccine, MenAfriVac, on carriage of serogroup A Neisseria meningitidis and disease transmission

, 2013
Paul A. Kristiansen
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CONJUGATED POLYSACCHARIDE VACCINES

Infectious Disease Clinics of North America, 1999
The joining of polysaccharide antigens to various proteins can result in increased immunogenicity of vaccines composed of such antigens. This article discusses conjugated polysaccharide vaccines for Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitis.
H, Ahmad, E K, Chapnick
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Meningococcal conjugate vaccines

Expert Opinion on Pharmacotherapy, 2004
Neisseria meningitidis is a leading cause of bacterial meningitis and sepsis in the US, Europe and in many other parts of the world, including parts of sub-Saharan Africa (known as the African 'meningitis belt'). There are > 500000 cases of meningococcal disease annually with an estimated death toll of 135000 worldwide.
Shanta M, Zimmer, David S, Stephens
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Pneumococcal conjugate vaccines

Immunology Letters, 1991
We have prepared conjugates of pneumococcal type 4 polysaccharides (PS4) or oligosaccharides to tetanus toxoid using the carbodiimide method. The use of a spacer, 6-aminohexanoic acid, resulted in higher incorporation of carrier protein. Conjugates contained up to 10% free polysaccharide, but no free protein.
C C, Peeters, A M, Tenbergen-Meekes, B, Haagmans, D, Evenberg, J T, Poolman, B J, Zegers, G T, Rijkers   +6 more
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Combination conjugate vaccines

Expert Opinion on Drug Safety, 2006
Increasingly, more diseases are becoming vaccine preventable, but maintaining community and provider acceptance demands that the number of injections does not increase. Combination conjugate vaccines represent an inevitable and important advance. This paper reviews the efficacy and safety of combination conjugate vaccines, including immunological ...
Naor, Bar-Zeev, Jim P, Buttery
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Pneumococcal conjugate vaccine

Current Opinion in Pediatrics, 2001
Pneumococcal infections account for a significant proportion of bacterial infections in infants and children. The growing threat from pneumococci resistant to penicillin and other antimicrobials has led to increased pressure for the development of an effective vaccine.
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Meningococcal conjugate vaccines

Expert Opinion on Biological Therapy, 2005
Disease caused by Neisseria meningitidis is associated with high mortality rates and significant sequelae. Polysaccharide meningococcal vaccines have been available for > 20 years, and have been used in travellers to control outbreaks, and in some countries for adolescents entering college, although they provide only a short duration of immunity and do
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Glycoprotein conjugate vaccines

Vaccine, 1999
The polysaccharide capsule which surrounds bacterial species like Haemophilus influenzae, Streptococcus pneumoniae, Neisseria meningitidis, Salmonella typhi, is a potent virulence factor. It protects the bacterium from phagocytosis, but capsule specific antibodies plus complement binding to the capsule opsonise the organism for phagocytosis and ...
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Polysaccharide Conjugate Typhoid Vaccine

New England Journal of Medicine, 2001
There is a growing appreciation of the huge health threat posed by increasingly resistant infectious diseases, especially in tropical areas of the developing world.
R L, Guerrant, M, Kosek
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