Results 41 to 50 of about 72,317 (257)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Post-polymerisation functionalisation of conjugated polymer backbones and its application in multi-functional emissive nanoparticles

Nature Communications, 2018
Functionalisation of conjugated polymers is essential for performance in many applications, yet there are limited approaches to achieve this. Here the authors developed a method for the direct postpolymerisation modification of the aromatic backbone of ...
Adam Creamer, Christopher S. Wood, Philip D. Howes, Abby Casey, Shengyu Cong, Adam V. Marsh, Robert Godin, Julianna Panidi, Thomas D. Anthopoulos, Claire H. Burgess, Tingman Wu, Zhuping Fei, Iain Hamilton, Martyn A. McLachlan, Molly M. Stevens, Martin Heeney   +15 more
doaj   +1 more source

Performance Comparisons of Polymer Semiconductors Synthesized by Direct (Hetero)Arylation Polymerization (DHAP) and Conventional Methods for Organic Thin Film Transistors and Organic Photovoltaics

Molecules, 2018
C-C bond forming reactions are central to the construction of π-conjugated polymers. Classical C-C bond forming reactions such as the Stille and Suzuki coupling reactions have been widely used in the past for this purpose.
Arthur D. Hendsbee, Yuning Li
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Acceptor Copolymerized Axially Chiral Conjugated Polymers with TADF Properties for Efficient Circularly Polarized Electroluminescence

Advanced Science
Chiral conjugated polymer has promoted the development of the efficient circularly polarized electroluminescence (CPEL) device, nevertheless, it remains a challenge to develop chiral polymers with high electroluminescence performance.
Wen‐Long Zhao, Ke‐Ke Tan, Wei‐Chen Guo, Chen‐Hao Guo, Meng Li, Chuan‐Feng Chen   +5 more
doaj   +1 more source

Recent Developments in C–H Activation for Materials Science in the Center for Selective C–H Activation

Molecules, 2018
Organic electronics is a rapidly growing field driven in large part by the synthesis of π-conjugated molecules and polymers. Traditional aryl cross-coupling reactions such as the Stille and Suzuki have been used extensively in the synthesis of &pi ...
Junxiang Zhang, Lauren J. Kang, Timothy C. Parker, Simon B. Blakey, Christine K. Luscombe, Seth R. Marder   +5 more
doaj   +1 more source

Anisotropic assembly and fluorescence enhancement of conjugated polymer nanostructures

View, 2022
The electronic properties of conjugated polymers depend sensitively on their conformation and morphology. However, control over the morphology of conjugated polymers is highly challenging.
Xiaoju Men, Xiaofeng Fang, Zhihe Liu, Zhe Zhang, Changfeng Wu, Haobin Chen   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Intrinsically stretchable fully π-conjugated polymers with inter-aggregate capillary interaction for deep-blue flexible inkjet-printed light-emitting diodes

Nature Communications
Fully π-conjugated polymers consisting of plane and rigid aromatic units present a fantastic optoelectronic property, a promising candidate for printed and flexible optoelectronic devices.
Mingjian Ni, Zhiqiang Zhuo, Bin Liu, Xu Han, Jing Yang, Lili Sun, Yuekuan Yang, Jiangli Cai, Xiang An, Lubing Bai, Man Xu, Jinyi Lin, Quanyou Feng, Guohua Xie, Yutong Wu, Wei Huang   +15 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source