Results 231 to 240 of about 1,234,343 (276)

Cross-species translational modelling of targeted therapeutic oligonucleotides using physiologically based pharmacokinetics. [PDF]

J Pharmacokinet Pharmacodyn
Derbalah A, Stader F, Liu C, Zyla A, Abdulla T, Wu Q, Jamei M, Gardner I, Sepp A.   +8 more
europepmc   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Non-Traditional Luminescent Polyurethanes of <i>n</i>-π Electron Hybrid Structures with Varying Separation of Aromatic Rings. [PDF]

ACS Appl Polym Mater
Wang Z, Li Y, Zhang H, Jiang N, Xu J, Zhu D, Bryce MR.   +6 more
europepmc   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Heterologous Expression and Enzymatic Properties of β-Glucuronidase from <i>Clostridium perfringens</i> and Its Application in Bilirubin Transformation. [PDF]

Microorganisms
Wu Q, Guo Q, Yang F, Li M, Zhu Y, Xu B, Zhao L, Zhang S, Xie Y, Li F, Wu X, Xu D.   +11 more
europepmc   +1 more source

Polymerization and stability of actin conjugated with polyethylene glycol. [PDF]

Biophys Physicobiol
Sagara M, Hatori K.
europepmc   +1 more source

Nanoparticle vaccine based on the pre-fusion F glycoprotein of respiratory syncytial virus elicits robust protective immune responses. [PDF]

J Virol
Hu Z, Tian S, Zhou Y, Wang Y, Li Y, Zhang S, Wei P, Zhuang Z, Ren L, Liu J, Zang N, Yu R, Ding Y, Guo Y, Jing C, Chen H, Zhang C, Yao Y, Deng C, Wei R, Zhou P, Zou Y, Zhao D, Liu S, Fu M, Mo X, Peng G, Liu E, Zhao J, Li Y, Jin J.   +30 more
europepmc   +1 more source

Peptide-Engineered Seliciclib Nanomedicine for Brain-Targeted Delivery and Neuroprotection. [PDF]

Int J Mol Sci
He GZ, Lin WJ.
europepmc   +1 more source

siRNA as a criterion in host immunity and cancer immunotherapy: modulating factors and nano-conjugate based approach for intervention. [PDF]

Int J Biol Sci
Bhattacharjee R, Das D, Chakraborty S, Bhaduri R, Chattopadhyay S, Singla RK, Kumarasamy V, Gundamaraju R.   +7 more
europepmc   +1 more source