Results 1 to 10 of about 4,896 (243)

Integrative genomic analysis identifies associations of molecular alterations to APOBEC and BRCA1/2 mutational signatures in breast cancer

Molecular Genetics & Genomic Medicine, 2019
Background The observed mutations in cancer are the result of ~30 mutational processes, which stamp particular mutational signatures (MS). Nevertheless, it is still not clear which genomic alterations correlate to several MS.
Victor Trevino
doaj   +1 more source

The deubiquitinase Rpn11 functions as an allosteric ubiquitin sensor to promote substrate engagement by the 26S proteasome

Cell Reports
Summary: The 26S proteasome is the major compartmental protease in eukaryotic cells, responsible for the ATP-dependent turnover of obsolete, damaged, or misfolded proteins that are delivered for degradation through attached ubiquitin modifications ...
Zaw Min Htet, Ken C. Dong, Andreas Martin   +2 more
doaj   +1 more source

A simple and high-sensitivity method for analysis of ubiquitination and polyubiquitination based on wheat cell-free protein synthesis

BMC Plant Biology, 2009
Background Ubiquitination is mediated by the sequential action of at least three enzymes: the E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme) and E3 (ubiquitin ligase) proteins. Polyubiquitination of target proteins is also implicated
Seki Motoaki, Nozawa Akira, Takahashi Hirotaka, Shinozaki Kazuo, Endo Yaeta, Sawasaki Tatsuya   +5 more
doaj   +1 more source

Anthrax Toxin-Mediated Delivery of the Pseudomonas Exotoxin A Enzymatic Domain to the Cytosol of Tumor Cells via Cleavable Ubiquitin Fusions

mBio, 2013
Anthrax toxin proteins from Bacillus anthracis constitute a highly efficient system for delivering cytotoxic enzymes to the cytosol of tumor cells. However, exogenous proteins delivered to the cytosol of cells are subject to ubiquitination on lysines and
Christopher Bachran, Thomas Morley, Suzanne Abdelazim, Rasem J. Fattah, Shihui Liu, Stephen H. Leppla   +5 more
doaj   +1 more source

Feces derived allergens of Tyrophagus putrescentiae reared on dried dog food and evidence of the strong nutritional interaction between the mite and Bacillus cereus producing protease bacillolysins and exo-chitinases

Frontiers in Physiology, 2016
Tyrophagus putrescentiae (Schrank, 1781) is an emerging source of allergens in stored products and homes. Feces proteases are the major allergens of astigmatid mites (Acari: Acaridida).
Tomas eErban, Dagmar eRybanska, Karel eHarant, Bronislava eHortova, Jan eHubert   +4 more
doaj   +1 more source

The E3 ligase RAD18-mediated ubiquitination of henipavirus matrix protein promotes its nuclear-cytoplasmic trafficking and viral egress

Emerging Microbes and Infections
The nuclear-cytoplasmic trafficking of matrix proteins (M) is essential for henipavirus budding, with M protein ubiquitination playing a pivotal role in this dynamic process.
Dongning Jin, Linliang Zhang, Cheng Peng, Mingbin He, Weiwei Wang, Zhifei Li, Cong Liu, Jinhong Du, Jin Zhou, Lei Yin, Chao Shan, Yali Qin, Mingzhou Chen   +12 more
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Assesment of Protein Gene Product (Pgp9.5) Enzyme Activity Against Potential Peptide Substrate

Eurasian Journal of Medicine, 2019
Objective. PGP9.5 is a human neuron specific ubiquitin carboxylterminal hydolase that has been shown by immunuhistochemistry to be present selectively in ubiquitinated inclusions in chronic human degenerative disease.
İbrahim Pirim, Nilnur Eyerci
doaj  

QnAs with Michael L. Dustin. [PDF]

Proc Natl Acad Sci U S A, 2023
Ravindran S.
europepmc   +1 more source

The Ufd1 cofactor determines the linkage specificity of polyubiquitin chain engagement by the AAA+ ATPase Cdc48. [PDF]

Mol Cell, 2023
Williams C, Dong KC, Arkinson C, Martin A.   +3 more
europepmc   +1 more source

Amide ¹H and ¹⁵N NMR signal assignments of all naturally-occurring di-ubiquitins. [PDF]

Biomol NMR Assign
Kurbah I, Castañeda CA, Fushman D.
europepmc   +1 more source