Results 31 to 40 of about 6,676 (281)
Optineurin functions for optimal immunity [PDF]
, 2018 Optineurin (OPTN) was identified 20 years ago in a yeast-two-hybrid screen with a viral protein known to inhibit the cytolytic effects of tumor necrosis factor.
Slowicka, Karolina, van Loo, Geert
core +1 more source
Regulation of endoplasmic reticulum-associated protein degradation (ERAD) by ubiquitin [PDF]
, 2014 Quality control of protein folding inside the endoplasmic reticulum (ER) includes chaperone-mediated assistance in folding and the selective targeting of terminally misfolded species to a pathway called ER-associated protein degradation, or simply ERAD.
Goder, Veit, Lemus Rodríguez,Leticia
core +2 more sources
Experimental and Molecular Medicine, 2018 Experimental & molecular medicine Researchers may have found a new target for treatment of multiple myeloma (MM), a common type of blood cancer.
Lili Zhou +7 more
doaj +1 more source
Frontiers in Physiology, 2018 Structural and functional alterations of mitochondria are intimately linked to a wide array of medical conditions. Many factors are involved in the regulation of mitochondrial function, including cytokines, chaperones, chemokines, neurosteroids, and ...
Victoria O. Polyakova +10 more
doaj +1 more source
Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets [PDF]
, 2005 The polyubiquitin receptor Rpn10 targets ubiquitylated Sic1 to the 26S proteasome for degradation. In contrast, turnover of at least one ubiquitin-proteasome system (UPS) substrate, CPY*, is impervious to deletion of RPN10.
Deshaies, Raymond J. +4 more
core +1 more source
Frontiers in Microbiology, 2018 Ubiquitination is an essential protein modification in eukaryotic cells, which is reversible. Deubiquitinating enzymes (DUBs) catalyze deubiquitination process to reverse ubiquitination, maintain ubiquitin homeostasis or promote protein degradation by ...
Zhao Wang +5 more
doaj +1 more source
Mass spectrometry insights into a tandem ubiquitin-binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin [PDF]
, 2016 Unanchored polyubiquitin chains are emerging as importanregulators of cellular physiology with diverse roles paralleling those of substrate-conjugated polyubiquitin.
Banerjee +27 more
core +2 more sources
The Ubiquitination Machinery of the Ubiquitin System [PDF]
The Arabidopsis Book, 2014 The protein ubiquitin is a covalent modifier of proteins, including itself. The ubiquitin system encompasses the enzymes required for catalysing attachment of ubiquitin to substrates as well as proteins that bind to ubiquitinated proteins leading them to their final fate.
openaire +4 more sources
Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase promoting complex [PDF]
, 2014 The anaphase promoting complex (APC) is the crucial ubiquitin ligase targeting the regulatory machinery of the cell cycle. Emi1, a major modulator of APC activity, is thought to act competitively as a pseudosubstrate.
Kirschner, Marc W., Wang, Weiping
core +1 more source
Frontiers in Plant Science, 2017 Drought stress from soil or air limits plant growth and development, leading to a reduction in crop productivity. Several E3 ligases positively or negatively regulate the drought stress response.
Sang-Wook Han +3 more
doaj +1 more source