Results 31 to 40 of about 104,927 (134)

A 26 S protease subunit that binds ubiquitin conjugates.

Journal of Biological Chemistry, 1994
Ubiquitin-mediated proteolysis provides an important mechanism for regulating a variety of cellular processes. Ubiquitin-conjugated proteins are degraded by a 26 S protease that contains more than 30 different subunits.
Q. Deveraux, Vicença Ustrell, C. Pickart, M. Rechsteiner   +3 more
semanticscholar   +1 more source

The Pepper RING Finger E3 Ligase, CaDIR1, Regulates the Drought Stress Response via ABA-Mediated Signaling

Frontiers in Plant Science, 2017
Drought stress from soil or air limits plant growth and development, leading to a reduction in crop productivity. Several E3 ligases positively or negatively regulate the drought stress response.
Sang-Wook Han, Sung Chul Lee, Hyunhee Joo, Chae Woo Lim   +3 more
doaj   +1 more source

Integrative genomic analysis identifies associations of molecular alterations to APOBEC and BRCA1/2 mutational signatures in breast cancer

Molecular Genetics & Genomic Medicine, 2019
Background The observed mutations in cancer are the result of ~30 mutational processes, which stamp particular mutational signatures (MS). Nevertheless, it is still not clear which genomic alterations correlate to several MS.
Victor Trevino
doaj   +1 more source

K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair

Science Signaling, 2018
Mutations in the DNA-interacting patch of ubiquitin sensitize cells to DNA-damaging agents. DNA-bound ubiquitin coordinates DNA repair Ubiquitylation is a posttranslational modification that reversibly alters protein stability, activity, interactions, or
Pengda Liu, Wenjian Gan, Siyuan Su, Arthur V. Hauenstein, T. Fu, B. Brasher, Carsten Schwerdtfeger, A. Liang, Ming Xu, Wenyi Wei   +9 more
semanticscholar   +1 more source

The dynamics of linear polyubiquitin

Science Advances, 2020
A new efficient method for SAXS-driven simulations allows researchers to explain the dynamics of linear polyubiquitin. Polyubiquitin chains are flexible multidomain proteins, whose conformational dynamics enable them to regulate multiple biological ...
Alexander Jussupow, Ana C. Messias, R. Stehle, A. Geerlof, Sara M. Ø. Solbak, Cristina Paissoni, A. Bach, M. Sattler, C. Camilloni   +8 more
semanticscholar   +1 more source

The deubiquitinase Rpn11 functions as an allosteric ubiquitin sensor to promote substrate engagement by the 26S proteasome

Cell Reports
Summary: The 26S proteasome is the major compartmental protease in eukaryotic cells, responsible for the ATP-dependent turnover of obsolete, damaged, or misfolded proteins that are delivered for degradation through attached ubiquitin modifications ...
Zaw Min Htet, Ken C. Dong, Andreas Martin   +2 more
doaj   +1 more source

A simple and high-sensitivity method for analysis of ubiquitination and polyubiquitination based on wheat cell-free protein synthesis

BMC Plant Biology, 2009
Background Ubiquitination is mediated by the sequential action of at least three enzymes: the E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme) and E3 (ubiquitin ligase) proteins. Polyubiquitination of target proteins is also implicated
Seki Motoaki, Nozawa Akira, Takahashi Hirotaka, Shinozaki Kazuo, Endo Yaeta, Sawasaki Tatsuya   +5 more
doaj   +1 more source

Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 reveal distinct binding mechanisms between substrate receptors and shuttle factors of the proteasome

Structure, 2016
SUMMARY Three receptors (Rpn1/S2/PSMD2, Rpn10/S5a, Rpn13/Adrm1) in the proteasome bind substrates by interacting with conjugated ubiquitin chains and/or shuttle factors (Rad23/HR23, Dsk2/PLIC/ubiquilin, Ddi1) that carry ubiquitinated substrates to ...
Xiang Chen, Leah Randles, K. Shi, S. Tarasov, H. Aihara, K. Walters   +5 more
semanticscholar   +1 more source

Anthrax Toxin-Mediated Delivery of the Pseudomonas Exotoxin A Enzymatic Domain to the Cytosol of Tumor Cells via Cleavable Ubiquitin Fusions

mBio, 2013
Anthrax toxin proteins from Bacillus anthracis constitute a highly efficient system for delivering cytotoxic enzymes to the cytosol of tumor cells. However, exogenous proteins delivered to the cytosol of cells are subject to ubiquitination on lysines and
Christopher Bachran, Thomas Morley, Suzanne Abdelazim, Rasem J. Fattah, Shihui Liu, Stephen H. Leppla   +5 more
doaj   +1 more source

UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains

Molecules and Cells
Summary Ubiquitin chains define the fates of their modified proteins, often mediating proteasomal degradation in eukaryotes. Yet heterogeneity of intracellular ubiquitination has precluded systematically comparing the degradation capacities of different ...
L. Kiss, L. James, Brenda A. Schulman
semanticscholar   +1 more source