Results 241 to 250 of about 164,481 (302)

Conjugation frequency of ESBL- and pAmpC- E. coli in broiler chickens in vivo and in vitro. [PDF]

BMC Microbiol
Vargas D, Merle R, Friese A, Roesler U, Robé C.   +4 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Clinical characteristics and molecular epidemiology of KPC-NDM co-producing carbapenem-resistant Klebsiella pneumoniae in China: a multicentre retrospective case-control study. [PDF]

EBioMedicine
Li X, Han X, Tang X, Fan Z, Ding L, Geng R, Chen Q, Huang J, Yao J, Zhou L, Du X, Liu J, Xie Y, Sun S, Yu H, Ma R, He J, Fu Y, Zhou H, Yu Y.   +19 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

H pilin cyclisation and pilus biogenesis are promiscuous but electrostatic perturbations impair conjugation efficiency. [PDF]

Nat Commun
He S, Ishimoto N, Wong JLC, David S, Sanchez-Garrido J, Bogdanov M, Beis K, Frankel G.   +7 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Lifestyle-associated variation in type IV secretion systems between phytopathogenic and environmental <i>Ralstonia</i>. [PDF]

Microb Genom
Cowell TC, Cope-Arguello ML, Shin GY, Bogdanove AJ, Carpenter SCD, Nahar K, Saha A, Lowe-Power TM.   +7 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Membrane perturbation by the last-resort antibiotic polymyxin B drives biphasic regulation of horizontal gene transfer. [PDF]

ISME J
Liang MQ, Yuan L, Liu QH, Wu J, Liu DF, Sheng GP.   +5 more
europepmc   +1 more source