Results 111 to 120 of about 916,358 (306)

Cohesion in journal articles on applied linguistics: the case of conjunction “thus”

open access: yesJournal of Applied Studies in Language, 2020
Cohesion plays an important role in building the readability and comprehension of a text. Instead of lexical, reference, substitution, and reference, conjunction is also important in a text.
Arina Isti’anah   +2 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

English coordinative conjunction but

open access: yes, 2018
This bachelor thesis will study English coordinating conjunction but. It is a coordinating conjunction which can connect not only the sentences (John is poor, but he is happy. (Quirk et al., 1985: 935)) but also various sentence elements (e.g. a modifier
Kozachukhnenko, Oksana
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Conjunction to criminal offence

open access: yes, 2008
Darbā “Piesaistība noziedzīgam nodarījumam” tiek aplūkoti jautājumi par piesaistības institūta vēsturisko attīstību 20.gs. Latvijas krimināllikumos, piesaistības noziedzīgam nodarījumam būtību Latvijas krimināltiesībās, piesaistības līdzību un atšķirību ...
Zalužinska, Līga
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Trace conjunction inequalities

open access: yes
Trace conjunction integrals are introduced and studied. They appear in trace conjunction inequalities which unify the Hardy inequality on a halfspace and the classical Gagliardo trace inequality.
Van Schaftingen, Jean
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Ortaokul Öğrencilerinin Bağlayıcı Bilgisi Üzerine Bir İnceleme

open access: yesUluslararası Filoloji Bengü
Bu çalışmanın temel amacı ortaokul öğrencilerinin bağlayıcı bilgi düzeylerini sınıf düzeyi, cinsiyet, okuma sıklığı ve yazma sıklığına göre incelemektedir.
Aziz Olcay Olğaç   +1 more
doaj   +1 more source

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