Results 81 to 90 of about 2,514,398 (283)

Ofsted framework for the inspection of local education authorities: draft [PDF]

open access: yes, 2003
Framework for the inspection of Local Education Authorities Effective from 1 January 2004 Office of Her Majesty’s Chief Inspector of Schools in conjunction with the Audit ...

core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Sustainable development in learning and skills inspections : guidance for inspectors [PDF]

open access: yes, 2012
"Learning and skills inspectors should read this guidance in conjunction with the Common Inspection Framework, to take account of providers’ contributions to a sustainable future" -- front ...

core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A compact spectroradiometer for solar simulator measurements [PDF]

open access: yes, 1972
Compact spectral irradiance probe has been designed and built which uses wedge filter in conjunction with silicon cell and operational amplifier.
Davidson, G. A.   +2 more
core   +1 more source

Multiple giant resonances in nuclei: their excitation and decay

open access: yes, 2003
The excitation of multiphonon giant resonances with heavy ions is discussed. The conventional theory, based on the use of the virtual photon number method in conjunction with the harmonic model is presented and its shortcomings are discussed.
Aumann   +31 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Improved design of electrophoretic equipment for rapid sickle-cell-anemia screening [PDF]

open access: yes, 1974
Effective mass screening may be accomplished by modifying existing electrophoretic equipment in conjunction with multisample applicator used with cellulose-acetate-matrix test paper.
Hirsch, I., Reddick, J. M.
core   +1 more source

Propagating Conjunctions of AllDifferent Constraints

open access: yes, 2010
We study propagation algorithms for the conjunction of two AllDifferent constraints. Solutions of an AllDifferent constraint can be seen as perfect matchings on the variable/value bipartite graph.
Bessiere, Christian   +4 more
core   +5 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

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