Results 61 to 70 of about 32,996 (168)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Mits vindt zichzelf opnieuw uit. Het gelexicaliseerde ja, mits als nieuwe gebruiksvorm
Acta Universitatis Carolinae Philologica, 2019 Grammar and style books restrain the use of mits to a few grammatical constructions. Language users do not care about those restrictions and tend to vary, but always in respect to the semantic regularity described by Saskia Daalder: mits p, q (with q ...
Gert Loosen
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Functioning of the word combination “da vsio ravno” in modern Russian language
Studia HumanitatisThe article examines the use of the word combination “da vsio ravno” by modern native speakers of Russian using examples from the Russian National Corpus. This combination includes the polyfunctional word “da”, which can act as an adversative conjunction
Krylova Maria Nikolaevna
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Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Slavia MeridionalisAsyndetic Complementation in the Light of Explicative Syntax (Exemplified with Bulgarian, Polish and Ukrainian) The subject of the study is Bulgarian, Polish and Ukrainian syntactic constructions in which the position of the clausal complement is ...
Aleksander Kiklewicz
doaj +1 more source
"The cohesion of foregrounding in Gwendolyn Brook's ''Michael is Afraid of the Storm '' and '' Martin Luther King Jr.'' Dr. Jihan Hassan Mohammad [PDF]
سرديات, 2019 This paper deals with cohesion of foregrounding in of foregrounding in Gwendolyn Brook's ''Michael is Afraid of the Storm'' and ''Martin Luther King Jr.''.This linguistic phenomenon is inevitable: it almost exists in every literary text.
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Certain Issues With the Commutativity of the Connective “i”
Studia Semiotyczne, 2020 DOI: http://doi.org/10.26333/stsen.xxxi.05 The conjunctive “i” is one of the four interpretations of the Polish connective “i” (“and” in English), along with the accessory, sequential and explicatory ones, which are distinguished by Olgierd ...
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