Results 131 to 140 of about 494,310 (275)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Integrated Representations of Threat and Controllability in the Lateral Frontal Pole. [PDF]

J Cogn Neurosci
Stasiak JE, Wang J, Dundon NM, Rizor EJ, Villanueva CM, Barandon PL, Grafton ST, Lapate RC.   +7 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

hGen: A Random CNF Formula Generator for Hybrid Languages

, 2003
hGen is a random CNF (conjunctive normal form) generator of formulas for sublanguages of H(@,\downarrow, A)
Areces, Carlos, Heguiabehere, Juan
core   +1 more source

Attenuated pupillary response during visual search in preclinical Alzheimer's disease. [PDF]

Alzheimers Dement
Festa EK, Heindel WC, Marangi CA, Escobedo B, Galasko DR, Salmon DP, Zou J, Jacobs DM.   +7 more
europepmc   +1 more source

A digital twin reproducing gene regulatory network dynamics of early Ciona embryos indicates robust buffers in the network. [PDF]

PLoS Genet, 2023
Tokuoka M, Satou Y.
europepmc   +1 more source

A study of a positive fragment of path queries : expressiveness, normal form and minimization

, 2011
: We study the expressiveness of a positive fragment of path queries, denoted Path+, on documents that can be represented as node-labeled trees. The expressiveness of Path+ is studied from two angles.
Wu, Yuqing, Gyssens, Marc, Paredaens, Jan, van Gucht, Dirk   +3 more
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source