Results 51 to 60 of about 16,037 (203)

Kinetics of Antibody Responses and Effector Cell Sensitivity After High Dose Birch Extract Nasal Challenge

Allergy, EarlyView.
High‐dose birch‐extract nasal challenge induced synchronous peaks at 4 weeks in serum specific IgE (sIgE) and basophil sensitivity. Mast cell sensitivity via tSPT and sIgG1 and sIgG4 responses peaked later, at 6–8 weeks. Preseasonal allergen exposure attenuated seasonal sIgE increase and prevented further rise in tSPT sensitivity.
N. J. Campion, S. Villazala‐Merino, C. Morgenstern, L. Nemec, V. Stanek, A. Tu, M. Zghaebi, J. Toth, R. Fröschl, T. Perkmann, M. Bastl, K. Gangl, S. Schneider, H. Breiteneder, R. Ristl, M. Focke‐Tejkl, R. Valenta, V. Niederberger‐Leppin, J. Eckl‐Dorna   +18 more
wiley   +1 more source

Type‐2‐Inflammatory‐Diseases Share Comorbidities, Molecular Signatures, IL4/IL13 Genetics, and Response to IL4/IL13 Blockade

Allergy, EarlyView.
Studies suggest that type 2 inflammatory diseases are driven by overactivation of the IL4/IL13 pathway, manifesting differently in distinct tissues. We performed quantitative analyses using several large independent datasets to explore the interrelation of type 2 inflammatory diseases based on co‐prevalence, genetic predispositions, and transcriptomic ...
Jennifer D. Hamilton, Manuel A. R. Ferreira, Wei Keat Lim, Carlo Sidore, Matthew F. Wipperman, Wenzhen Ge, Xue Song, Changming Xia, Julie E. Horowitz, Andrea T. Hooper, Sara C. Hamon, Jennifer Maloney, Jamie M. Orengo, Zhen Chen, Stephanie Amato Ricci, Bolanle Akinlade, Aris Baras, Gary Herman, Brandy L. Bennett, George D. Yancopoulos   +19 more
wiley   +1 more source

The Early Efficacy of Topical Levocabastine in Patients with Allergic Conjunctivitis

Allergology International, 2006
Background: We investigated the early efficacy of topical levocabastine, an H1 histamine-receptor antagonist, in improving the clinical symptoms of allergic conjunctivitis. Methods: Thirty-six patients with allergic conjunctivitis were enrolled. One drop
Hiroshi Fujishima, Kazumi Fukagawa, Yoji Takano, Shigeki Okamoto, Yayoi Nakagawa, Eiichi Uchio, Norihiko Yokoi, Atsuki Fukushima, Etsuko Takamura   +8 more
doaj   +1 more source

Preventive Application of House Dust Mite‐Sublingual Immunotherapy Induces Blocking Antibodies in Sensitized Preschool Children

Allergy, EarlyView.
HDM‐pSLIT induced IgG, IgG1, and IgG4 specific to major HDM allergens in sensitized non‐allergic preschool children without increasing HDM‐sIgE. It blunted the development of new sensitizations and reduced HDM reactivity in skin and basophils. HDM‐pSLIT treated children displayed a blocking effect on HDM‐induced basophil activation.
Varsha Dwivedi, Klara Schmidthaler, Hilal Demir, Justyna Sieber, René Gaupmann, Livia Mia Gona‐Höpler, Christina Bannert, Saskia Gruber, Eleonora Dehlink, Thomas Eiwegger, Alexandra Graf, Barbara Bohle, Zsolt Szépfalusi   +12 more
wiley   +1 more source

Efficacy and Safety of Dupilumab in Chinese Adult Patients With Chronic Rhinosinusitis With Nasal Polyps: A Randomized, Placebo‐Controlled, Phase III Trial

Allergy, EarlyView.
Dupilumab significantly improved nasal polyp score, nasal congestion, olfaction, total symptom score, and disease‐specific quality of life in Chinese patients with uncontrolled CRSwNP. Incidence of treatment‐emergent adverse events was similar between dupilumab and placebo.
Mu Xian, Menglin Wang, Changqing Zhao, Lijia Wan, Yu Xu, Juan Meng, Rui Xu, Xicheng Song, Li Shi, Yucheng Yang, Yan Jiang, Yanzhen Wu, Bethany Ling, Vivian Li, Andrew P. Fontenot, Lacey R. Robinson, Neelam A. Phadke, Chengshuo Wang, Luo Zhang   +18 more
wiley   +1 more source

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source

Altered hyaluronic acid content in tear fluid of patients with adenoviral conjunctivitis

Anais da Academia Brasileira de Ciências, 2015
The adenoviral conjunctivitis is one of the biggest causes of conjunctival infection in the world. Conjunctivitis causes relatively nonspecific symptoms, as hyperaemia and chemosis.
JULIANA L. DREYFUSS, CAIO V. REGATIERI, BRUNO COELHO, JOSÉ B. BARBOSA, DENISE DE FREITAS, HELENA B. NADER, JOÃO R. MARTINS   +6 more
doaj   +1 more source

Optimizing the treatment for dry eye syndrome in patients with allergic conjunctivitis

Journal of Ophthalmology, 2020
Background: Allergic conjunctivitis is commonly complicated by secondary dry eye syndrome that substantially affects the quality of life of patients and requires a comprehensive approach to treatment.
F.A. Bakhritdinova, S.A. Mirrakhimova, K.I. Narzikulova, Zh.O. Safarov, O.I. Oripov   +4 more
doaj   +1 more source

Reported Symptoms Upon Exposure to Aeroallergen Highly Predict Allergen Sensitization Among 12‐Year‐Old Children

Acta Paediatrica, EarlyView.
ABSTRACT Aim To evaluate the association between reported symptoms upon exposure to airborne allergens and sensitization to the corresponding allergen. Method In a population‐based cohort, 1647 children aged 12 years were interviewed about symptoms from eyes, nose and lower airways upon exposure to birch, timothy, cat, dog, and horse, and were ...
E. Rönmark, L. Lundevall, A. Bjerg, R. Johansson, A. Winberg, L. Hedman   +5 more
wiley   +1 more source

Relationship between allergic rhinitis and allergic conjunctivitis (allergic rhinoconjunctivitis) - review. [PDF]

Rom J Ophthalmol, 2022
Iordache A, Boruga M, Mușat O, Jipa DA, Tătaru CP, Mușat GC.   +5 more
europepmc   +1 more source