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Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery +25 more
wiley +1 more source

Ocular Surface Diseases Induced by Dupilumab in Severe Atopic Dermatitis

Ophthalmology and Therapy, 2019
We report 10 cases of conjunctivitis in atopic dermatitis (AD) patients treated with dupilumab from November 2017 to November 2018 in our institution, who were referred to the ophthalmology department for diagnosis and management of conjunctivitis.
Adrien Maudinet +5 more
doaj +1 more source

A One‐Strength Dose Escalation Regimen for Birch Pollen SCIT Is Safe and Tolerable in Children, Adolescents, and Adults

Allergy, EarlyView.
This study evaluated safety and tolerability of birch pollen SCIT during dose escalation with a new One‐Strength regimen (3 injections, Strength B) compared to the Standard regimen (7 injections, Strengths A and B) in patients aged 5–65 years. Safety and tolerability were comparable between the two regimens in adults, adolescents, and adolescents, as ...
Marek Jutel +5 more
wiley +1 more source

Patient‐Perceived Benefits of Named‐Patient Product Sublingual Immunotherapy in Allergic Rhinitis and Asthma: Primary Results From the ERAPP Real‐World Cohort Study

Allergy, EarlyView.
Evaluation en vie Réelle de l'Allergo‐Prescription en Pratique (ERAPP) is a large, prospective, real‐world cohort of children and adults initiating named‐patient product sublingual immunotherapy (NPP‐SLIT) in France. More than 80% of patients reported a clinically meaningful, expectation‐anchored benefit (Patient Benefit Index ≥ 1) at 12–15 months. The
Davide Caimmi +9 more
wiley +1 more source

Conjunctivitis: Types, Clinical Manifestation and Management

JLUMHS
This narrative review analyses the different types, clinical manifestations, and management strategies for conjunctivitis to facilitate accurate diagnosis and treatment planning.
Mehwish Rubab, Sana Zahoor, Saba Ashraf
doaj +1 more source

Allergic Rhinitis and Its Impact on Asthma (ARIA)‐EAACI Guidelines—2024–2025 Revision: Part II—Guidelines on Oral and Ocular Treatments

Allergy, EarlyView.
ABSTRACT Background Oral and ocular medications are frequently used in the treatment of allergic rhinitis (AR). As part of the update of the Allergic Rhinitis and its Impact on Asthma (ARIA)‐EAACI guidelines, this manuscript presents the ARIA‐EAACI 2024–2025 recommendations for oral and ocular treatments.
Rafael José Vieira +230 more
wiley +1 more source

Chinese Position Paper on Biologic Therapy for Allergic Rhinitis

Allergy, EarlyView.
ABSTRACT Allergic rhinitis (AR) is a common, persistent nasal disorder that poses significant public health challenges worldwide. Current treatment options frequently fail to achieve adequate symptom control in a substantial subset of patients. Over the past two decades, biologic therapies that target type 2 inflammatory pathways have been used to ...
Yuan Zhang +37 more
wiley +1 more source

Conjunctivitis in the newborn- A comparative study

Indian Journal of Pathology and Microbiology, 2011
Background: Conjunctivitis of the newborn is defined as hyperemia and eye discharge in the neonates and is a common infection occurring in the neonates in the first month of life. In the United States, the incidence of neonatal conjunctivitis ranges from
Meenakshi Wadhwani +5 more
doaj +1 more source

What is the incidence and clinical significance of dry eye disease in patients treated with immune checkpoint inhibitors? A systematic review and meta‐analysis of ocular immune‐related adverse events

Acta Ophthalmologica, EarlyView.
Abstract Purpose Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but may cause immune‐related adverse events (irAEs), including dry eye disease (DED). This study aimed to quantify the incidence of ICI‐associated DED and to evaluate factors contributing to variability across studies.
Kai‐Yang Chen, Hoi‐Chun Chan, Chi‐Ming Chan +2 more
wiley +1 more source

THE EFFECT OF ALLERGIC CONJUCTIVITIS ON CHOROIDAL THICKNESS

Sanamed, 2019
Background: To examine the effects of allergic conjunctivitis and its treatment upon choroidal thickness (ChT) using topical antihistaminic agents. Methods: 60 eyes of 30 children and adolescents with allergic conjunctivitis and 60 eyes of 30 healthy ...
Ayyildiz Taha, Yilmaz Mevlut, Ayyildiz Didem +2 more
doaj +1 more source

humans
3. good health
allergic conjunctivitis

ophthalmology
female
child

conjunctivitis, allergic
conjunctiva
anti-bacterial agents