Results 81 to 90 of about 2,522,495 (283)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Essential p-dimension of algebraic groups whose connected component is a torus
, 2012 Following up on our earlier work and the work of N. Karpenko and A. Merkurjev, we study the essential p-dimension of linear algebraic groups G whose connected component G^0 is a torus.Comment: 23 pages, no figures.
Aurel Meyer +14 more
core +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
S-Shaped Connected Component for Nonlinear Fourth-Order Problem of Elastic Beam Equation
Journal of Function Spaces, 2017 We investigate the existence of S-shaped connected component in the set of positive solutions of the fourth-order boundary value problem: u′′′′x=λhxfux, x∈(0,1),u(0)=u(1)=u′′0=u′′1=0, where λ>0 is a parameter, h∈C[0,1], and f∈C[0,∞) with f0≔lims→0(f(s ...
Jinxiang Wang, Ruyun Ma, Jin Wen
doaj +1 more source
Abstract Harmonic Analysis on the General Linear Group GL(n,R) [PDF]
, 2014 Consider the general linear group, which is not connected but rather has two connected components, the matrices with positive determinant and the ones with negative determinant. Consider the Iwasawa decomposition of its special linear group. We adopt the
El-Hussein, Kahar
core
Character sheaves on disconnected groups, X
, 2008 We classify the unipotent character sheaves on a fixed connected component of a reductive algebraic group under a mild hypothesis on the characteristic of the ground field.Comment: 67 ...
Lusztig, G.
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
The largest strongly connected component in Wakeley et al's cyclical pedigree model [PDF]
, 2014 We establish a link between Wakeley et al's (2012) cyclical pedigree model from population genetics and a randomized directed configuration model (DCM) considered by Cooper and Frieze (2004).
Blath, Jochen +2 more
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