Results 61 to 70 of about 232,724 (277)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
3-Factor-criticality in double domination edge critical graphs [PDF]
, 2014 A vertex subset $S$ of a graph $G$ is a double dominating set of $G$ if $|N[v]\cap S|\geq 2$ for each vertex $v$ of $G$, where $N[v]$ is the set of the vertex $v$ and vertices adjacent to $v$.
Shan, Erfang +2 more
core
Discussiones Mathematicae Graph Theory, 2021 In this paper, we study a new distance parameter triameter of a connected graph G, which is defined as max{d(u; v)+d(v;w)+d(u;w) : u; v;w ∈ V }and is denoted by tr(G).
Das Angsuman
doaj +1 more source
Split Domination Number in Edge Semi-Middle Graph
Pan-American Journal of Mathematics, 2022 Let G = (p, q) be a connected graph and Me(G) be its corresponding edge semi-middle graph. A dominating set D ⊆ V [Me(G)] is split dominating set V [Me(G)] – D is disconnected.
Venkanagouda M. Goudar +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Valency based domination number for Mycielskian of some graphs [PDF]
Mathematics and Computational SciencesLet G = (V, E) be a connected graph and γvb(G) denotes the valency based domination number of G or simply vb-domination number of G. In this paper, analogous to isolated vertex in domination, defined valency based isolated vertex (or simply, vb-isolated ...
Kavitha Thilakan +1 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Total outer-connected domination numbers of trees
Discrete Applied Mathematics, 2009 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Cyman, Joanna, Raczek, Joanna
openaire +1 more source