Results 121 to 130 of about 1,805,611 (347)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Pβ-connectedness in topological spaces
Demonstratio Mathematica, 2017 A new property called Pβ-connectedness is introduced which is stronger than connectedness and equivalent to pre-connectedness. The properties of this notion are explored and its relationship with other forms of connectedness, for example ...
Tyagi Brij K. +2 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
ABC Connectedness to Nature Scale
, 2022 Here you can found the two SPSS database to replicate the analyses for the validation of the ABC Connectedness to Nature Scale, validated in a paper published at the Environmental Education Research (doi: 10.1080/13504622.2022.2111407).Peer ...
Cuadrado, Esther
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
, 2019 Objective: School connectedness has been found to be protective against negative health behaviours for adolescents. This study assesses 1) the extent that school connectedness is an attribute of the school, and 2) whether the protective associations of ...
MacLellan, Margaret
core
Connectedness of Uncertainty, Volatility, and Stock Market Performance
Journal of Banking and Financial EconomicsThis study examines the dynamic connectedness and spillover effects among various financial and economic indicators, including uncertainty indices, market volatility, and stock market indices, from 3 June 2008, to 30 December 2024.
Szczepan Urjasz
doaj +1 more source
Ecology and Society, 2011 The adaptive cycle constitutes a heuristic originally used to interpret the dynamics of complex ecosystems in response to disturbance and change. It is assumed that socially constructed governance systems go through similar phases (K, Ω [omega], α [alpha]
Katrin Daedlow +2 more
doaj +1 more source