Results 131 to 140 of about 1,805,611 (347)

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Teachers' understandings of pedagogic connectedness [PDF]

open access: yes, 2006
This paper is based on a doctoral study that attempts to operationalise the productive pedagogy initiative of Education Queensland. Ths study identified the qualitatively different ways in which middle years teachers may experience pedagogic ...
Beutel, Denise A., Beutel, Denise Ann
core   +1 more source

Dynamic Connectedness Among Key Financial Markets and the Role of Policy Uncertainty: A Quantile-Based Approach

open access: yesRisks
This paper investigates the return spillover dynamics among carry trade, stock, foreign exchange, and commodity markets to identify their roles as net transmitters or receivers of shocks under varying market conditions.
Lumengo Bonga-Bonga
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Artificial Intelligence and Financial Market Connectedness: Evidence from AI-Related Equities, Cryptocurrencies, and Global Assets

open access: yesFinTech
The rapid expansion of artificial intelligence (AI), particularly with the rise of generative AI technologies, has attracted increasing attention in financial markets.
Shigeyuki Hamori
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Assessing Economic Complexity with Input-Output Based Measures [PDF]

open access: yes
Economic complexity can be defined as the level of interdependence between the component parts of an economy. In input-output systems, intersectoral connectedness is a crucial feature of analysis, and there are many different methods for measuring it ...
J. Ferreira do Amaral   +2 more
core  

Community place attachment as a significant correlate of motivation to change substance use behavior among adults who inject drugs in rural U.S.

open access: yesFrontiers in Public Health
IntroductionWhile motivation is critical for substance use disorder (SUD) recovery, many individuals fail to engage in treatment. The need to belong is a fundamental human motivation, yet the role of community place attachment (CPA) as a social asset in ...
Janet K. Otachi   +4 more
doaj   +1 more source

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