Results 101 to 110 of about 1,357,146 (299)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The Negative Impact of Vehicular Intelligence on Energy Consumption

Journal of Advanced Transportation, 2019
The development of intelligent vehicle will provide the Chinese automotive industry with a strategic opportunity for transformation and upgrading. Vehicular intelligence provides new solutions for energy conservation and emissions mitigation.
Zongwei Liu, Hong Tan, Xu Kuang, Han Hao, Fuquan Zhao   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Connecting the ESG factors to banks’ financial performance and sustainability: the need for strategic alignment

Cogent Business & Management
This study examines the impact of Environmental, Social, and Governance (ESG) disclosure on bank performance in the MENA region, addressing a critical gap in research on emerging economies.
Miroslav Mateev, Ahmad Sahyouni, Syed Moudud-Ul-Huq   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Studying the Impact of Geometric Characteristics of Internal Tubes in Expansion Mufflers on Sound Transmission Loss [PDF]

بهداشت و ایمنی کار
Introduction: A significant contributor to noise pollution in urban areas is automobile exhaust systems, wherein mufflers, as passive devices, are designed to mitigate the noise produced.
Iraj Alimohammadi, Mahdi Farrokhi, Sevda Javadi, Mozhgan Nouraei, Leila Hosseini Shafeie   +4 more
doaj  

Why It Takes So Long to Connect to a WiFi Access Point

, 2017
Today's WiFi networks deliver a large fraction of traffic. However, the performance and quality of WiFi networks are still far from satisfactory. Among many popular quality metrics (throughput, latency), the probability of successfully connecting to WiFi
Meng, Yuan, Pei, Changhua, Pei, Dan, Peng, Yuanquan, Qu, Xiaodong, Tang, Wenliang, Wang, Zhi, Wang, Zihan, Zhao, Youjian   +8 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Applying an Indigenous Connectedness Framework to Examine Environmental Risk and Protective Factors for Urban American Indian Children’s Executive Function Development

Behavioral Sciences
Indigenous frameworks suggest environmental risk and protective factors for American Indian (AI) children’s development can be understood in terms of connecting and disconnecting forces in five domains: spirituality, family, intergenerational ties ...
Alexis Merculief, Monica Tsethlikai, Felix Muniz   +2 more
doaj   +1 more source

Measurement of inclusive jet spectra in pp, p-Pb, and Pb-Pb collisions with the ALICE detector

, 2014
Highly energetic jets are sensitive probes for the kinematic properties and the topology of high energy hadron collisions. Jets are collimated sprays of charged and neutral particles, which are produced in fragmentation of hard scattered partons from an ...
Haake, Rüdiger
core   +1 more source