Results 51 to 60 of about 993,171 (249)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Blind spots in health perception: the underestimated role of social connection for health outcomes

BMC Public Health
Background Robust evidence indicates that having few or poor-quality social connections is associated with poorer physical health outcomes and risk for earlier death (Snyder-Mackler N, Science 368, 2020; Vila J, Front Psychol 12:717164, 2021).
Andrew Scot Proctor, Julianne Holt-Lunstad   +1 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Optimal scheduling model using the IGDT method for park integrated energy systems considering P2G–CCS and cloud energy storage

Scientific Reports
To enhance the energy efficiency and financial gains of the park integrated energy system (PIES). This paper constructs a bi-level optimization model of PIES-cloud energy storage (CES) based on source-load uncertainty.
Lixin Wang, Jing Cheng, Xu Luo
doaj   +1 more source

A 7-Year-Old Extrauterine Pregnancy in a Cat

Case Reports in Veterinary Medicine, 2014
This paper describes a 7-year-old extrauterine pregnancy in a spayed cat. Three extrauterine fetuses were accidentally found in the abdomen of a 12-year-old domestic short hair cat that had ovariohysterectomy about 7 years before.
Agata Osenko, Walter Tarello
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

CO2 Joule-Thomson effect: Application on premium connections for CCS well

Carbon Capture Science & Technology
CCS (Carbon Capture and Storage) is a major technology aiming to reduce greenhouse gases and reduce carbon footprint. In these applications, Oil Country Tubular Goods (OCTG) and associated premium connections are used to inject industrial CO2 into stable
Laurent Boufflers, Pierre Martin, Pierre Mauger, Diana Rodriguez   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The Theory of Connections: Connecting Points [PDF]

Mathematics, 2017
This study introduces a procedure to obtain all interpolating functions, y = f ( x ) , subject to linear constraints on the function and its derivatives defined at specified values. The paper first shows how to express these interpolating functions passing through a single point in three distinct ways: linear, additive, and rational. Then, using
openaire   +4 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source