Results 61 to 70 of about 5,732,477 (296)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Earth: the apple of our eye [PDF]

, 1994
Grade Level(s): 4-6A visual demonstration illustrates the limits on farmland, making the importance of conservation clear.Counting on ...
Population Connection
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Cultivating a Global Connection [PDF]

, 2018
A Hassenfeld Fellow’s transatlantic teaching experience demonstrates the impact of experiential learning through cultural ...
Rubin, Julia
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Blind spots in health perception: the underestimated role of social connection for health outcomes

BMC Public Health
Background Robust evidence indicates that having few or poor-quality social connections is associated with poorer physical health outcomes and risk for earlier death (Snyder-Mackler N, Science 368, 2020; Vila J, Front Psychol 12:717164, 2021).
Andrew Scot Proctor, Julianne Holt-Lunstad   +1 more
doaj   +1 more source

Connection space reduction mechanism [PDF]

, 1992
A connector assembly comprised of two halves, each respectively including a shell type connector subassembly, one being an active half and the other being a passive half is described.
Milam, Malcolm Bruce
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Optimal scheduling model using the IGDT method for park integrated energy systems considering P2G–CCS and cloud energy storage

Scientific Reports
To enhance the energy efficiency and financial gains of the park integrated energy system (PIES). This paper constructs a bi-level optimization model of PIES-cloud energy storage (CES) based on source-load uncertainty.
Lixin Wang, Jing Cheng, Xu Luo
doaj   +1 more source

A 7-Year-Old Extrauterine Pregnancy in a Cat

Case Reports in Veterinary Medicine, 2014
This paper describes a 7-year-old extrauterine pregnancy in a spayed cat. Three extrauterine fetuses were accidentally found in the abdomen of a 12-year-old domestic short hair cat that had ovariohysterectomy about 7 years before.
Agata Osenko, Walter Tarello
doaj   +1 more source