Results 81 to 90 of about 1,028,037 (267)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Voltage abnormity prediction method of lithium-ion energy storage power station using informer based on Bayesian optimization

Scientific Reports
Accurately detecting voltage faults is essential for ensuring the safe and stable operation of energy storage power station systems. To swiftly identify operational faults in energy storage batteries, this study introduces a voltage anomaly prediction ...
Zhibo Rao, Jiahui Wu, Guodong Li, Haiyun Wang   +3 more
doaj   +1 more source

Connecting connections

, 2008
As true as it is that a bricklayer needs a plumb line and a T-square, so it is that a physicist using general relativity needs how to draw geodesics and use fields of congruent vector frames of reference. While the first part of the preceding statement depends on the Christoffel connection and related metric and curvature concepts, the second part ...
openaire   +2 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Barriers to finding and maintaining pet-inclusive affordable housing: Tenant experiences in Houston, Texas

Frontiers in Veterinary Science
The city of Houston, Texas has a growing deficit of available and affordable rental units for low-income residents. Due to pet policies, the shortage of affordable housing potentially puts renters who own pets at greater risk of housing insecurity.
Tess M. Mascitelli, Taryn M. Graham, Lauren Loney, Jennifer W. Applebaum, Christa M. Murray, Miranda Binns-Calvey, Sloane M. Hawes, Kevin Morris   +7 more
doaj   +1 more source

The connected cutset connectivity of a graph

Discrete Mathematics, 1988
The connected (edge-)cutset connectivity \(c\kappa\) (G) \((c\kappa_ 1(G))\) of a graph G is the minimum cardinality of a vertex (edge) cutset S of G such that the subgraph induced by S is connected. Let \(\kappa\) (G) be the vertex-connectivity of G, \(\kappa_ 1(G)\) the edge-connectivity and \(\delta\) (G) the minimal degree.
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Modeling and simulation analysis of multi-scenario air conditioning cluster response for intelligent load management in distribution networks

Scientific Reports
This paper proposes a dynamic multi-scenario modeling approach for air conditioning (AC) cluster loads, integrating occupant behavior, spatiotemporal activity distributions, and meteorological factors.
ZhiYong Zhang, HaiYun Wang
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source