Results 51 to 60 of about 2,175,475 (311)

Under-Connected and Over-Connected Networks [PDF]

open access: yesSSRN Electronic Journal, 2009
Since the seminal contribution of Jackson & Wolinsky 1996 [A Strategic Model of Social and Economic Networks, JET 71, 44-74] it has been widely acknowledged that the formation of social networks exhibits a general conflict between individual strategic behavior and collective outcome.
Buechel, Berno, Hellmann, Tim
openaire   +6 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Measuring the One Health impacts associated with creating access to veterinary care before and during the COVID-19 pandemic

open access: yesFrontiers in Public Health
Integrating community perceptions into One Health assessments is critical to understanding the structural barriers that create disproportionate health outcomes for community members, their pets, and the ecosystems that encompass them, particularly in ...
Sloane M. Hawes   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Flexibility Robust Optimal Operation Strategy for Cross-Regional Interconnected Power Under Load-Source Coordination

open access: yesIEEE Access, 2020
Ultra High Voltage (UHV) transmission technology is the main regional power interconnection method in China. In addition, renewable energy sources (RES) in China are characterized by centralized distribution.
Xiaozhu Li   +4 more
doaj   +1 more source

About connections [PDF]

open access: yesFrontiers in Neuroanatomy, 2015
Despite the attention attracted by "connectomics", one can lose sight of the very real questions concerning "What are connections?" In the neuroimaging community, "structural" connectivity is ground truth and underlying constraint on "functional" or "effective" connectivity.
Kathleen S Rockland, Kathleen S Rockland
openaire   +3 more sources

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Blind spots in health perception: the underestimated role of social connection for health outcomes

open access: yesBMC Public Health
Background Robust evidence indicates that having few or poor-quality social connections is associated with poorer physical health outcomes and risk for earlier death (Snyder-Mackler N, Science 368, 2020; Vila J, Front Psychol 12:717164, 2021).
Andrew Scot Proctor   +1 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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