Results 41 to 50 of about 91,202,407 (238)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Impact of Children’s Connection to Nature. A Report for the Royal Society of the Protection of Birds (RSPB) [PDF]

, 2016
Connecting with nature should be part of every child’s life as it has the potential to aid nature’s revival while benefiting the child. To embed nature connection within our social norms, there is a need to be able to understand the benefits and set ...
Harvey, C., Petronzi, D., Sheffield, D., Richardson, M.   +3 more
core  

One thousand good things in Nature: aspects of nearby Nature associated with improved connection to Nature [PDF]

, 2015
As our interactions with nature occur increasingly within urban landscapes, there is a need to consider how ‘mundane nature’ can be valued as a route for people to connect to nature.
Lumber, R., Richardson, Miles, Jenny Hallam, Lumber, Ryan, Ryan Lumber, Miles Richardson, Hallam, Jenny, Hallam, J., Richardson, M.   +8 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Connection to nature and pro-environmental behavior among children in Jakarta: the role of experiences of nature [PDF]

Psicologia USP
: This study aims to examine whether connection to nature mediates the relationship between children’s experiences of nature and their pro-environmental behavior in Jakarta.
Indah Rizki Wulandari, Ade Iva Murty, Muhammad Akhyar   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

‘A deep, empathetic, wondrous connection’: Autistic adults' definitions and experiences of nature connection

People and Nature
Connection to nature is an important concept for understanding human‐nature relationships, interests in nature and pro‐environmental behaviours. However, conceptualisations of this relationship thus far have excluded autistic perspectives.
Samantha Friedman, Sara McHaffie, Roan Noble, Anna Stenning   +3 more
doaj   +1 more source

Diet Quality is Positively Associated With Nature Relatedness in a U.S. Population: A Pilot Study

Preventive Medicine Reports
Background: Sustainable dietary practices can help reduce greenhouse gas emissions and promote planetary health. The importance of investigating how to promote sustainable dietary practices is therefore crucial.
Dahlia Stott, Jonathan M. Deutsch, Micheal Bruneau, Jr., Jennifer A. Nasser, Mara Z. Vitolins, Brandy-Joe Milliron   +5 more
doaj   +1 more source