Results 51 to 60 of about 478,401 (253)
The natural connectivity of autonomous systems
Rivista Italiana di Filosofia del Linguaggio, 2020 The principle of biological autonomy, introduced by Francisco J. Varela, addresses the dilemma of Cartesian mind-body dualism by re-casting mind and body, or subject and object, observer and observed, not as irreconcilable categories, but as complementary perspectives on the same biological phenomena.
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Creativity Studies, 2023 There has been research on the significance of placemaking as a process for user health and well-being and how that affects their way of life in urban planning and development.
Shanta Pragyan Dash, N. Lakshmi Thilagam
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
People and NatureReconnecting young people with nature is increasingly recognized as critical for human and planetary well‐being, yet opportunities for youth to form these connections are shrinking.
Bryn Spielvogel +3 more
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Education SciencesIn Australia and around the world, young students are increasingly experiencing declines in wellbeing, engagement, and sense of belonging. These trends are accompanied by rising anxiety and social disconnection that affect learning and development.
Alexandra Harper +2 more
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Les modes d’appropriations de l’espace « vague » sur le littoral français
Géographie et Cultures, 2011 The surf riding experiencing known constant development over the past forty years and the entire French coastline is invested by riders: surfers, of course, but also windsurfers and kitesurfers.
Guillaume Mariani
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Frontiers in Psychology, 2020 Zoos attract millions of visitors every year, many of whom are schoolchildren. For this reason, zoos are important institutions for the environmental education of future generations.
Matthias Winfried Kleespies +7 more
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