Results 81 to 90 of about 14,177 (220)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Language as a mechanism for reasoning about possibilities. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2022 Grigoroglou M, Ganea PA.
europepmc +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
A Modal Interpretation of Quantum Spins and Its Application to Freudian Theory. [PDF]
Entropy (Basel), 2022 Battilotti G, Borozan M, Grotto RL.
europepmc +1 more source
Non-Fregean Logics of Analytic Equivalence (II) [PDF]
, 2015 This paper presents the main assumptions of Andrzej Grzegorczyk’s last research project concerning the logic of synonymity. It shows that the basis of logic of analytic equivalence, presented in the first part of the work, fully corresponds with these ...
Biłat, Andrzej
core
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Inferences from the negation of counterfactual and semifactual conditionals. [PDF]
Mem Cognit, 2022 Espino O, Orenes I, Moreno-Ríos S.
europepmc +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Revisiting Reichenbach's logic. [PDF]
Synthese, 2021 Estrada-González L, Cano-Jorge F.
europepmc +1 more source