Results 231 to 240 of about 4,769,883 (431)

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Glutathione has cell protective and anti-catabolic effects in articular cartilage without impairing the chondroanabolic phenotype

open access: yesHeliyon
Joint injuries and consequent oxidative stress is a high-risk factor for developing post-traumatic osteoarthritis (OA). While antioxidative therapy using N-acetylcysteine (NAC) has cell- and chondroprotective effects following cartilage injury, it ...
Svenja Maurer   +3 more
doaj  

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Recent developments in connective tissue disease associated pulmonary arterial hypertension

open access: yesInternational Journal of Cardiology Congenital Heart Disease
Connective tissue disease associated pulmonary arterial hypertension (CTD-PAH) has benefited from the major treatment advances that have occurred within pulmonary hypertension over the past three decades.
Stefano Rodolfi   +2 more
doaj  

Physiologic relevance of the transpulmonary metabolome in connective tissue disease-associated pulmonary vascular disease. [PDF]

open access: yesJCI Insight
Lee MH   +18 more
europepmc   +1 more source

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