Results 51 to 60 of about 18,789 (283)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Prognosis of complicated clinical course of varicose veins of lower extremities on the basis of analysis of phenotypic characteristics of connective tissue dysplasia [PDF]

Саратовский научно-медицинский журнал, 2015
Aim: to identify the phenotypic characteristics of indeterminate connective tissue dysplasia, which help to predict the progression of varicose veins of lower extremities and disease recurrence after surgery. Material and Methods.
Tsarev О.А., Anisimov A.Yu., Zakharov N.N.   +2 more
doaj  

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Connective tissue dysplasia — medical-social phenomenon of the XXI century

Bolʹ, Sustavy, Pozvonočnik, 2012
The article describes the morphological and pathogenetic aspects of the formation of connective tissue dysplasia, the diagnostic criteria of this pathology, described in detail the manifestations of connective tissue dysplasia of heart and respiratory ...
Z.V. Nesterenko
doaj   +1 more source

Risk factors for venous thrombosis in patients with endoprosthetics of hip joints

Journal of Education, Health and Sport, 2021
Background. Important part of orthopaedic surgery is endoprosthetics of hip joints, which eliminates pain syndrome, restores the amplitude of movements and the support ability of the lower limb.
Ihor Venher, Sviatoslav Kostiv, Dymytrii Khvalyboha   +2 more
doaj   +1 more source

Pancreatic Atrophy: A Narrative Review and Surgical Interpretation

Annals of Gastroenterological Surgery, EarlyView.
Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino, Ken‐ichi Okada, Yohei Masugi, Eisuke Iwasaki, Masaki Mori   +4 more
wiley   +1 more source

Xstainer: A Novel Virtual Staining Tool Powered by Advanced Deep Learning Techniques

Advanced Intelligent Systems, EarlyView.
Xstainer is a deep learning–based virtual staining framework that converts hematoxylin and eosin‐stained whole slide images into multiple histochemical stains, including Masson's trichrome, Periodic acid‐Schiff, Jones methenamine silver, and Toluidine blue.
Fatma Nur Kinali, Derya Demir, Kutsev B. Ozyoruk, Yasin Almalioglu, Emre C. Kose, Drew F. K. Williamson, Gurdeniz Serin, G. Evren Keles, Banu S. Kumbaraci, Ceren Utku, Uguray P. Hacisalihoglu, Ilknur Turkmen, Figen Ozturk, Kayhan Basak, Yavuz Nuri Ertas, Mehmet Turan   +15 more
wiley   +1 more source

РОЛЬ ДИСПЛАЗИИ СОЕДИНИТЕЛЬНОЙ ТКАНИ (НАСЛЕДСТВЕННЫХ НАРУШЕНИЙ СОЕДИНИТЕЛЬНОЙ ТКАНИ) В ИЗМЕНЕНИИ ЭЛАСТИЧЕСКИХ СВОЙСТВ АРТЕРИЙ

Архивъ внутренней медицины, 2012
The article reviews the influence of connective tissue dysplasia in the formation of vascular wall rigidity on the basis of literature. Substantiates the importance of studying the role and prospects of connective tissue dysplasia in changing the elastic
О. В. Дрокина, А. А. Семенкин, Г. И. Нечаева, С. Ф. Гюнтер, Н. Н. Туморина   +4 more
doaj   +1 more source

Undifferentiated connective tissue dysplasia is a predictor of perinatal complications [PDF]

, 2019
В статье рассматриваются вопросы возможных исходов беременности и родов у женщин с различными клиническими проявлениями недифференцированной дисплазии соединительной ткани (ДСТ), а также особенности течения раннего неонатального периода у новорожденных ...
Сац, Ю.Н., Novitskaya, Т., Sats, J., Новицкая, Т.В.   +3 more
core  

Therapeutic Silencing of Tmprss6 Reduces Iron‐Induced Inflammation and Prolongs Survival in MDS Mice

American Journal of Hematology, EarlyView.
ABSTRACT Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and an increased risk of progression to acute myeloid leukemia (AML). Despite advances in supportive and targeted therapies, disease‐modifying interventions remain limited.
Shahla Vilcassim, Nuttanan Pholngam, Rattanawan Thubthed, Tiwaporn Nualkaew, Saovaros Svasti, Pornthip Chaichompoo, Kai Kysenius, Peter J. Crouch, Sibylle Dames, Mona Eisermann, Alberto Martinez, Ute Schaeper, Jim Vadolas, George Grigoriadis   +13 more
wiley   +1 more source