Results 31 to 40 of about 425,897 (267)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Flexible multi-node simulation of cellular mobile communications: the Vienna 5G System Level Simulator

open access: yesEURASIP Journal on Wireless Communications and Networking, 2018
The investigation and prediction of new trends and technologies for mobile cellular networks is of utmost importance for researchers and network providers to quickly identify promising developments.
Martin Klaus Müller   +8 more
doaj   +1 more source

Structural Connectivity Alterations in Operculo-Insular Epilepsy

open access: yesBrain Sciences, 2021
Operculo-insular epilepsy (OIE) is an under-recognized condition that can mimic temporal and extratemporal epilepsies. Previous studies have revealed structural connectivity changes in the epileptic network of focal epilepsy.
Sami Obaid   +11 more
doaj   +1 more source

To Be Connected, or Not to Be Connected [PDF]

open access: yesProceedings of the 2017 ACM on Conference on Information and Knowledge Management, 2017
In Proceedings of the 26th ACM conference on Information and Knowledge Management (CIKM 2017)
Natali Ruchansky   +4 more
openaire   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Learning from volcanic eruptions: Co-production of knowledge at Merapi and Kelud, Indonesia

open access: yesJàmbá
The increasing frequency and intensity of volcanic disasters present major challenges for rural communities, particularly in terms of recovery and the restoration of environmental conditions post-crisis.
Nuzul Solekhah   +9 more
doaj   +1 more source

Assaying Mechanonociceptive Behavior in Drosophila Larvae

open access: yesBio-Protocol, 2018
Drosophila melanogaster larvae have been extensively used as a model to study the molecular and cellular basis of nociception. The larval nociceptors, class IV dendritic arborization (C4da) neurons, line the body wall of the animal and respond to various
Nina Hoyer   +3 more
doaj   +1 more source

Linking spontaneous and stimulated spine dynamics

open access: yesCommunications Biology, 2023
Our brains continuously acquire and store memories through synaptic plasticity. However, spontaneous synaptic changes can also occur and pose a challenge for maintaining stable memories.
Maximilian F. Eggl   +4 more
doaj   +1 more source

Rainbow Connection in 3-Connected Graphs [PDF]

open access: yesGraphs and Combinatorics, 2012
An edge-colored graph $G$ is rainbow connected if any two vertices are connected by a path whose edges have distinct colors. The rainbow connection number of a connected graph $G$, denoted by $rc(G)$, is the smallest number of colors that are needed in order to make $G$ rainbow connected.
Xueliang Li 0001, Yongtang Shi
openaire   +3 more sources

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