Results 41 to 50 of about 1,464,688 (300)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural Connectivity Alterations in Operculo-Insular Epilepsy

open access: yesBrain Sciences, 2021
Operculo-insular epilepsy (OIE) is an under-recognized condition that can mimic temporal and extratemporal epilepsies. Previous studies have revealed structural connectivity changes in the epileptic network of focal epilepsy.
Sami Obaid   +11 more
doaj   +1 more source

Universal Negative Poisson Ratio of Self Avoiding Fixed Connectivity Membranes [PDF]

open access: yes, 2001
We determine the Poisson ratio of self-avoiding fixed-connectivity membranes, modeled as impenetrable plaquettes, to be sigma=-0.37(6), in statistical agreement with the Poisson ratio of phantom fixed-connectivity membranes sigma=-0.32(4).
A. Cacciuto   +38 more
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

On the strengths of connectivity and robustness in general random intersection graphs [PDF]

open access: yes, 2014
Random intersection graphs have received much attention for nearly two decades, and currently have a wide range of applications ranging from key predistribution in wireless sensor networks to modeling social networks.
Gligor, Virgil, Yağan, Osman, Zhao, Jun
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Flexible multi-node simulation of cellular mobile communications: the Vienna 5G System Level Simulator

open access: yesEURASIP Journal on Wireless Communications and Networking, 2018
The investigation and prediction of new trends and technologies for mobile cellular networks is of utmost importance for researchers and network providers to quickly identify promising developments.
Martin Klaus Müller   +8 more
doaj   +1 more source

Immunization of complex networks [PDF]

open access: yes, 2002
Complex networks such as the sexual partnership web or the Internet often show a high degree of redundancy and heterogeneity in their connectivity properties. This peculiar connectivity provides an ideal environment for the spreading of infective agents.
Pastor-Satorras, Romualdo   +1 more
core   +2 more sources

Connection structures.

open access: yesNotre Dame Journal of Formal Logic, 1991
The authors investigate a calculus of individuals based on a primitive notion of connectedness. They show that their system of axioms leads to complete orthocomplemented lattices whereas the extension of their system to the Clarke system leads to complete atomless Boolean algebras [see also \textit{B. Clarke}, ibid. 26, 61-75 (1985; Zbl 0597.03005)].
Biacino, Loredana, Gerla, Giangiacomo
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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