Results 61 to 70 of about 846,964 (298)

Hydrological Connectivity - a study into representative metrics for a humid temperate catchment in northern England. [PDF]

, 2011
Hydrological connectivity has been identified as a concept which can help hydrology move towards a hydrological approach focussing on homogeneity rather than difference.
WILLIAMS, CHRISTOPHER,JOHN,SELLWOOD
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Single-Cell RNA-Seq Reveals Developmental Origins and Ontogenetic Stability of Neurexin Alternative Splicing Profiles

Cell Reports, 2019
Summary: Neurexins are key synaptic organizers that are expressed in thousands of alternatively spliced isoforms. Because transsynaptic neurexin interactions with different postsynaptic molecules are largely isoform dependent, a cell type-level census of
David Lukacsovich, Jochen Winterer, Lin Que, Wenshu Luo, Tamas Lukacsovich, Csaba Földy   +5 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Accuracy Assessment of Digital Terrain Model Dataset Sources for Hydrogeomorphological Modelling in Small Mediterranean Catchments

Remote Sensing, 2018
Digital terrain models (DTMs) are a fundamental source of information in Earth sciences. DTM-based studies, however, can contain remarkable biases if limitations and inaccuracies in these models are disregarded.
Lukas Graf, Mariano Moreno-de-las-Heras, Maurici Ruiz, Aleix Calsamiglia, Julián García-Comendador, Josep Fortesa, José A. López-Tarazón, Joan Estrany   +7 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Maintenance of cell type-specific connectivity and circuit function requires Tao kinase

Nature Communications, 2019
It is unclear how circuit specificity and function are maintained during organismal growth. In this study, authors show that connectivity between primary nociceptors and their downstream neurons scales with animal size and that Ste20-like kinase Tao acts
Federico Marcello Tenedini, Maria Sáez González, Chun Hu, Lisa Hedegaard Pedersen, Mabel Matamala Petruzzi, Bettina Spitzweck, Denan Wang, Melanie Richter, Meike Petersen, Emanuela Szpotowicz, Michaela Schweizer, Stephan J. Sigrist, Froylan Calderon de Anda, Peter Soba   +13 more
doaj   +1 more source

Connected locally connected toposes are path-connected [PDF]

Transactions of the American Mathematical Society, 1986
A conjecture of A. Joyal is proved, which states that, in contrast to topological spaces, toposes which are connected and locally connected are also path-connected. The reason for this phenomenon is the triviality of cardinality considerations in the topos-theoretic setting; any inhabited object pulls back to an enumerable object under some open ...
Moerdijk, I., Wraith, G. C.
openaire   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Constrained-MMSE Combining for Spatial Domain Self-Interference Cancellation in Full-Duplex Massive MIMO Systems

IEEE Open Journal of the Communications Society
This paper introduces a novel spatial domain-based self-interference cancellation (SIC) method named constrained minimum mean square error (C-MMSE) for massive multiple-input multiple-output (mMIMO) full-duplex (FD) communication systems.
Xuan Chen, Vincent Savaux, Matthieu Crussiere, Patrick Savelli, Koffi-Clement Yao   +4 more
doaj   +1 more source